乙酰苯胺的合成

Synthesis of Acetanilide

以苯胺、乙酸酐、乙酸为原料合成乙酰苯胺,考察了乙酸酐用量、乙酸用量、反应时间对乙酰苯胺收率的影响。确定了最佳工艺条件:n(苯胺):n(乙酸):n(乙酸酐)=1:2.0:0.2,反应时间为4.5 h。此条件下,乙酰苯胺收率达98.2％～98.4％,纯度达99.58％～99.82％。

The acetanilide was synthesized from phenylamine, acetic anhydride, and acetic acid. The effects of reaction time, amounts of acetic anhydride and acetic acid on the yield of acetanilide were investigated. The optimum conditions of synthesis were determined as follows: n (phenylamine) : n (acetic acid) : n (acetic anhydride) = 1: 2.0 : 0.2, reaction time was 4.5 h. The yield and purity of acetanilide was up to 98 .2 % - 98 .4 % and 99.58 % -99 .82 % respectively.