扩散加权成像ADC值评价非酒精性脂肪肝严重程度的初步研究

A Preliminary Study of Diffusion Weighted Imaging Apparent Diffusion Coefficient in Assessing Hepatic Steatosis Grade of Nonalcoholic Fatty Liver Disease

目的探讨肝脾CT值比值与扩散加权成像ADC值的相关性,研究扩散加权成像ADC值对脂肪肝患者的严重程度分级的可行性。方法回顾性收集在我院影像科检查的患者80例,所有的患者均行CT和MRI扫描,包括正常对照组(n=20)、轻度脂肪肝组(n=20)、中度脂肪肝组(n=20)及重度脂肪肝组(n=20)。通过分析肝脾CT值比值与ADC值的相关性及比较四组样本的ADC值间的差异来评估ADC值对脂肪肝患者的严重程度分级的可行性。以P<0.05认为差异具有显著统计学意义。结果肝脾的CT值比值与ADC值之间存在显著的正相关(r=0.954,P<0.05);肝实质的平均A D C值:正常肝实质(1.451±0.123)×10^(-3)mm^2/sec,轻度脂肪肝(1.341±0.014)×10^(-3)mm^2/sec,中度脂肪肝(1.206±0.007)×10^(-3)mm^2/sec,重度脂肪肝(1.040±0.017)×10^(-3)mm^2/sec,组间比较差异均具有显著的统计学意义(P<0.05)。结论肝脾CT值比值与ADC值具有显著正相关性,ADC值对肝细胞脂肪变性的严重程度分级诊断是可行的。

Objective To explore the relationship between CT value of liver-to-spleen ratio and ADC value in the patients with fatty liver, and investigate the feasibility of ADC value in assessing hepatic steatosis grade of nonalcoholic fatty liver disease. Methods Eighty patients were analyzed retrospectively in this study, all the patients were performed CT and MRI examination, including normal group 01=20）, mild fatty liver group （n=20）, moderate group （n=20） and severe fatty liver group （n=20）. The correlation analysis between CT value of liver-to-spleen ratio and AI）C value was evaluated, and differences among four groups were also analyzed in this study. P〈0.1）5 was considered as statistical significant difference. Results There was significant positively correlation between CT value of liver-to-spleen ratio and ADC value （r=0.954, P〈0.05）, and ADC value of liver parenchymal： normal group （1.451 ± 0.123） ×10^-3mm^2/sec, mild fatty liver （1.341 ± 0.014） ×10^-3mm^2/sec, moderate fatty liver （1.206 ±0.007） ×10^-3mm^2/sec, severe fatty liver （1.040± 0.017） ×10^-3mm^2/sec, there was significant statistical difference among four groups （all P〈0.05）： Conclusion There was significant positively correlation between CT value of liver-to-spleen ratio and ADC value, ADC value could be available for evaluating hepatic steatosis grade of nonalcoholic fatty liver disease.