一例环孢素引起外周神经系统损害的病例分析

Cyclosporine-induced peripheral nervous system toxicity–a case report

目前,关于环孢素引起的外周神经系统损害报道甚少,其具体机制也尚不明确。环孢素引起的外周神经系统损害似乎与血药浓度无关,只有在停用药物后神经系统损害方可减轻或消失。本文通过对一例57岁膜性肾病患者服用环孢素一个月后引起外周神经病变、停药后症状才缓解的病例进行分析,以期对临床合理用药提供参考。

At present, there have been only a few reports about cyclosporine-associated peripheral nervous system toxicity and its mechanism is still uncertain. The blood concentration seems to be not associated with cyclosporin-related neurotoxicity. The damage can only be reduced or disappeared after the drug is discontinued. Here, we reported a case of 57 years old patient with membranous nephropathy to whom peripheral nervous system toxicity occurred after he was treated with cyclosporine for one month, and his symptoms were relieved only after the withdrawal of cyclosporine, so as to provide reference for clinical safe medication.