肺炎支原体感染与支气管哮喘气道炎症及急性发作的相关性研究

目的研究肺炎支原体（MP）感染与支气管哮喘气道炎症及急性发作的相关性，为临床优化治疗寻找方法。方法收集2015年2月至2016年5月期间确诊收治的85例支气管哮喘患者和64例普通感冒患者为观察对象，分别记为观察纽和对照纽，均于入院2d内进行血清特异性MP抗体检测（MP-IgM），比较两组MP-IgM阳性率；根据MP-IgM检测结果，观察组进一步进行外周血嗜酸性粒细胞计数（EOS）和血清总IgE检查，比较MP-IgM阳/阴性对气道炎症反应的影响；根据上述检测结果整理，比较观察组中急性期、缓解期患者的指标差异，采用Peaeson法分析MP感染和支气管哮喘急性发作的相关性。结果观察组MP—IgM阳性率34．12％（29／85）较对照组3．13％（2／64）高，差异具有统计学意义（P〈0．05）；29例MP-IgM阳性支气管哮喘患者EOS计数、血清总IgE分别较56例MP-IgM阴性支气管哮喘患者检测值高，差异具有统计学意义（P〈0.05）；上述检测记录整理显示支气管哮喘急性期患者MP—IgM阳性率、EOS计数、血清总IgE分别较缓解期高，差异均具有统计学意义（P〈O．05）；Pearson,S＆性分析显示MP—IgM阳性率和支气管哮喘患者EOS计数、血清总IgE呈高度正相关关系（r=0．749、0．512）。结论MP感染是支气管哮喘发病的重要因素，和气道炎症、病情发作程度密切相关，急性发作期患者行MP-IgM检测有助于全面了解患者病情，为临床优化治疗提供参考依据。

Objective To study the relationship between the infection of Mycoplasma pneumoniae （ MP ） and the bronchial asthma airway inflammation and acute attack, to offer clinical optimization treatment method. Methods 85 cases of patients with bronchial asthma and 64 cases of common cold in our hospital from February 2015 to May 2016 were selected, patients were recorded in the observation group and the control group, the serum specific MP antibody test （MP-IgM） were performed within 2 hours after hospital admission, the MP-Igpositive rates of patients were compared between two groups. According to MP-Ig test results, patients of observation group were examined peripheral blood eosinophils count （ EOS ） and total serum IgE. The effect of MP-Ig positive / negative on airway inflammation were compared. According to the above test results, the indicator difference of patients of the observation group in the acute phase, and the remission stage were compared. Peaeson method was used to analyze the relationship between MP infection and acute attack of bronchial asthma. Results The positive rate of MP-IgM of patients of the observation group was 34.12% （ 29/85 ） higher than 3.13% （ 2/64 ） of patients of the control group, the difference had statistical significance （ P〈0.05 ） . EOS count, total serurnMP-IgM of 29 cases of patients with MP-IgM positive bronchial asthma were higher detection value compared with 56 cases of MP-IgM negative bronchial asthma patients, the difference had statistical significance （ P〈0.05 ） . The above test records showed that MP-IgM positive rate, EOS count and total serum MP-IgM of patients with acute bronchial acute phase were higher than those of remission stage, the differences had statistical significances （ P〈0.05 ） . Pearson correlation analysis showed that the positive rate of MP-IgM was highly positive correlation with EOS counts, total serum MP-IgM of patients with bronchial asthma （ r=0.749、 0.512 ） . Conclusion MP-IgM infection is an important factor in the occurance of bronchial asthma and it is closely related to airway inflammation, the severity of the disease. Patients with acute exacerbation of MP-IgM test is helpful for a comprehensive understanding of the patient＇s condition and provide reference for clinical optimization treatment.