复方丹参滴丸对扩张型心肌病患者心功能和MMP-9的影响

目的观察复方丹参滴丸对扩张型心肌痛心力衰竭患者的辅助治疗效果。方法将扩张型心肌痛心功能Ⅲ级的患者随机分为对照组和观察组，每组各35例。观察组在抗心衰标准药物治疗基础上加用复方丹参滴丸，90d后进行疗效对比评定，观察两组心功能、射血分数、6min步行试验和MMP-9的变化。结果治疗后两组各项指标较治疗前均有明显改善（P〈0．01），两组除临床疗效和MMP-9有显著性差异外，余结果差异无统计学意义（P〉0．05）。结论复方丹参滴丸配合标准抗心衰药物能明显缓解扩张型心肌病心力衰竭患者的症状；复方丹参滴丸组与对照组比较可以改善心肌纤维化，可能与MMP-9降低有关，确切机制值得进一步探讨。

Objective To observe the clinical effect of compound Danshen dripping pill on treating chronic heart failure of dilated cardiomyopathy （ DCM ） . Methods 70 CHF patients with NYHA heart function classification for grade Ⅲ were randomly divided into control group and study group with 35 cases in each group. The control group was given standard anti-heart failure drug therapy while the study group was treated with compound Danshen dripping pill on the basis of standard anti-heart failure drug therapy. The changes of cardiac function, ejection fraction, 6min walking test and MMP-9 in two groups were evaluated on 90 days after treatment. Results After treatment, two groups＇ indicators were obviously improved （ P〈0.01 ） ; There was significant difference between the two groups in clinical efficacy and MMP-9 （P〈0.05） ,while others showed no significant difference （ P〉0.05 ） . Conclusion Compound Danshen dripping pill combined with routine anti-heart failure drug therapy can alleviate the symptoms of chronic heart failure patients. Study group can improve myocardial fibrosis compared with the control group may be associated with reduced MMP-9 and the mechanism is worthy of further study.