乳腺癌874例临床及病理分析

目的通过免疫组化方法检测乳腺癌组织中雌激素受体（ER）、孕激素受体（PR）、CerbB．2蛋白的表达，分析其与·晦床病理因素和生存的关系。方法收集2000年2月至2012年5月经病理确诊的乳腺癌手术标本共874例，采用EnVision二步法对术后肿瘤石蜡标本进行ER、PR、CerbB．2检测，并与患者的年龄、原发肿瘤病理类型和服淋巴结转移状况、5年生存率相结合进行分析。结果ER、PR表达率与患者年龄无相关性（P〉0．05）；ER和PR表达呈正相关，差异有统计学意义（P〈0．05）；ER表达与CerbB-2呈负相关，差异有统计学意义（P〈0.05）；PR表达与CerbB-2表达无相关性（P〉0．05）。组织病理学类型和腋淋巴结转移与ER、PR、CerbB-2表达均无相关性（P〉0．05）。ER阴性和CerbB-2阳性增加了死亡风险。结论乳腺癌患者ER、PR与CerbB-2表达有一定规律，与临床病理因素联合应用对判断预后有一定意义。

Objective To detect the expression of estrogen receptor （ ER ） , progesterone receptor （ PR ） and CerbB-2 protein in breast cancer tissue by immunohistoehemical method, to analyze the relationship between the clinical pathologic factors and survival. Methods Regression analyses were performed for 874 breast cancer patients from February 2000 to may 2011, using EnVision two steps to test the levels of ER, PR and CerbB-2 of the paraffin specimens. Results There was no correlation between the ER and PR expression and patients age （ P〉0.05 ） ; there were positively correlation between the expressions of ER and PR （ P〈0.05 ） , and negatively correlation between ER and CerbB-2 （ P〈0.05 ） , and no correlation between PR and CerbB-2 （ P〈0.05 ） .There was also no correlation between histopathological type, axillary lymph node metastasis and the expression of ER, PR and CerbB-2 （P〉0.05 ） . ER negative and CerbB-2 positive increased the risk of death. Conclusion The expressions of ER, PR and CerbB-2 in breast cancer have certain regularity, and which combined with clinical pathologic factors have certain significance in estimating prognosis.