丁螺环酮联合氟伏沙明治疗强迫症的效果观察

目的观察丁螺环酮联合氟伏沙明治疗强迫症的效果。方法选择在我院住院治疗的76例强迫症患者为观察对象，随机分为对照组和观察组，每组各38例，对照组给予氟伏沙明治疗，观察组给予丁螺环酮联合氟伏沙明治疗，疗程8周，采用Y-BOS和HAVD评分；TESS评定副反应。结果两组Y-BOS及HAVD评分随着治疗时间的延长均有下降，但观察组下降明显低于对照组，差异有统计学意义（P〈0．05）。疗效方面观察组显效率为94．7％，高于对照组73．7％。两组不良反应发生率接近，差异无统计学意义（P〉0．05）。结论强迫症患者采用丁螺环酮联合氟伏沙明治疗起效快，效果明显，不增加副作用。

Objective To observe the effect of buspirone combined with fluvoxamine in treatment of obsessive-compulsive disorder. Methods 76 cases of hospitalized obsessive-compulsive disorder patients in our hospital were selected as the objects of study. They were randomly divided into the control group and the observation group, with 38 cases for each group. The control group was treated with fluvoxamine, while the observation group was treated with buspirone combined with fluvoxamine in the course of 8 weeks. Y-BOS and HAVD were adopted for scoring and TESS was adopted for assessing the side effects. Results The Y-BOS and HAVD scores of the both groups declined with the extension of the treatment time. However, the decrease of the observation group was obvious lower than that of the control group. The difference had statistical significance （ P〈0.05 ） . In respect of curative effect, the marked improvement rate of the control group was 94.7%, that higher than the control group of 73.7%. The incidence of the adverse reactions was similar between the both groups and the difference had no statistical significance （ P〉0.05 ） . Conclusions Buspirone combined with fluvoxamine in treatment of obsessive-compulsive disorder patients has rapid and obvious effect without additional side effect.