淋巴细胞亚群在肿瘤化疗后合并感染患者中的诊断价值

The Diagnostic Value of Lymphocyte Subsets in Patients With Tumor After Chemotherapy Combined Infection

目的探讨淋巴细胞亚群在肿瘤化疗后合并感染患者中价值分析。方法对2013年6月—2015年6月我院215例肿瘤化疗后合并感染患者进行回顾性分析,将患者分为真菌组、细菌组和病毒组。采用流式细胞仪对三组患者淋巴细胞亚群进行分析。结果细菌感染组患者的CD3^+细胞比例高于不明原因发热组和非细菌感染组(P<0.05),真菌组与病毒感染组差异无统计学意义(P>0.05);细菌感染组患者的CD4^+细胞比例和CD4^+/CD8^+细胞比值均高于真菌发热组(P<0.05),真菌组高于病毒感染组(P<0.05);病毒组患者的CD8+细胞比例高于真菌组和细菌感染组(P<0.05),真菌组与细菌感染组差异无统计学意义(P>0.05)。讨论在肿瘤化疗后发热诊断中,淋巴细胞亚群检测不仅可作为细菌感染的初步筛选指标,还可以此推断病原体、明确发热原因,针对性地指导临床用药治疗。

Objective Analysis the value of ymphocyte subsets in patients with tumor after chemotherapy combined infection.Methods 215 cases of patients with tumor after chemotherapy combined infection from 2013 to 2015,were retrospectively analyzed,and divided the patients into fungi group,bacteria group and viruses group.By using flow cytometry instrument lymphocyte subsets in patients with three groups were analyzed.Results Bacterial infection group had a significantly higher proportion of CD3^＋ cells in patients with fuo group and the bacterial infection group（P〈0.05）,fungal and viral infection group there was no significant difference（P〉0.05）;The proportion of CD4^＋ cells in patients with bacterial infection group and ratio of CD4^＋/CD8^＋ cells were significantly higher than fungi fever group（P〈0.05）,fungal infection is significantly higher than group（P〈0.05）;Virus group had a significantly higher percentage of CD8^＋ cells in patients with fungal and bacterial infection group（P〈0.05）,fungal and bacterial infection group there was no significant difference（P〉0.05）.Conclusion In tumor after chemotherapy fever diagnosis,lymphocyte subgroup detection preliminary screening indexes not only can be used as a bacterial infection,can also assume that pathogens,clear heat,targeted drug therapy in clinic.