乳腺癌组织中SOX10的表达及其与临床病理特征的相关性分析

Analysis the Correlation of SOX10 Expression in Breast Cancer Tissue and Clinicopathologic Feature

目的探究乳腺癌组织中SOX10的表达及其与临床病理特征的相关性。方法选择2015年12月—2016年12月我院收治的193例行乳腺癌切除术患者,收集正常乳腺组织和乳腺癌组织标本各193例。分析SOX10表达及其临床病理特征的相关性。结果在正常乳腺肌上皮细胞中SOX10的阳性率为100.00%,在成纤维细胞和乳腺腺腔细胞中未见SOX10表达;患者年龄、淋巴结转移、肿瘤大小与SOX10表达无关(P>0.05),分子分型与SOX10表达有关(P<0.05),在三阴型乳腺癌中SOX10阳性率为61.54%,在HER-2过表达型、腺腔A和B乳腺癌中未见SOX10表达,差异有统计学意义(P<0.05);SOX10兔抗人单克隆抗体(兔单抗EP268)只存在细胞核着色,SOX10兔抗人多克隆抗体(兔多抗abl08408)可同时出现胞质和胞核着色。结论在三阴型乳腺癌和乳腺肌上皮细胞中SOX10有表达,可将SOX10作为诊断两者的标志物。

Objective To investigate the correlation of sox10 expression in breast cancer tissue and clinicopathologic feature.Methods 193 cases with breast cancer resection in our hospital from December 2015 to December 2016 were selected and 193 cases of normal breast cancer tissue were chosen.Analyze SOX10 expression and its clinicopathologic feature.Results In normal myoepithelial cell,positive rate was 100%,there was no SOX10 expression in fibroblast and mammary gland cavity cell;age,lymphatic metastasis,tumor size had no relation with SOX10（P〈0.05）,molecular subtyping and SOX10 expression had relation（P〈0.05）,in triple negative breast cancer,positive rate of SOXl0 was 61.54%,there was no SOX10 expression in HER-2 over expression,glandular cavity A and B breast cancer,the difference was statistic significant（P〈0.05）;Rab Mab EP268 only existed in nucleus staining,rabbit polyclonal antibodies abl08408 can appeared simultaneously in cytoplasm and karyon.Conclusion SOXl0 expression has significant expression in triple negative breast cancer and myoepithelial cell and can be seen as marker for diagnosing.