静脉注射丙种球蛋白对儿童不敏感川崎病的临床价值分析

Analysis of Clinical Value of Intravenous Immunoglobulin is not Sensitive to the Kawasaki Disease in Children

目的研究静脉注射丙种球蛋白对儿童不敏感川崎病的临床价值。方法选取2014年1月-2016年1月儿童川崎病患儿76例,将其对丙种球蛋白的敏感性分为敏感组和非敏感组,同时对所有患儿继续采用静脉注射丙种球蛋白联合阿司匹林进行治疗,对比两组的实验室指标:血沉、白蛋白、C反应蛋白、中性粒细胞、白细胞、外周血血红蛋白,并对比治疗效果。结果敏感组白蛋白高于非敏感组,P<0.05;两组患儿血沉、中性粒细胞、白细胞、C反应蛋白、外周血血红蛋白比较,差异无统计学意义,P>0.05。经治疗2周,敏感组治疗效果优于非敏感组,P<0.05;经治疗6个月,两组治疗效果对比,差异无统计学意义,P>0.05。结论儿童不敏感川崎病的发生和白蛋白关系密切,继续反复采用静脉注射丙种球蛋白联合阿司匹林进行治疗可有效改善患儿病情。

Objective To study the effect of intravenous immunoglobulin for children is not sensitive to the clinical value of Kawasaki disease. Methods From January 2014 to January 2016 Kawasaki children＇s disease in children in 76 cases, the sensitivity of gamma globulin was divided into sensitive and non sensitive group, at the same time for all children to continue by intravenous injection of gamma globulin in combination with aspirin treatment, laboratory indexes of the two groups comparison： albumin, ESR, C reactive protein, neutrophil cells, white blood cells, peripheral blood hemoglobin, and compared treatment. Results The albumin in the sensitive group was higher than that in the non sensitive group, P〈0.05;Two groups of children with ESR, neutrophils, white blood cells, C was no significant difference in peripheral blood protein, hemoglobin, P〉0.05. After 2 weeks of treatment, the effect of the treatment group was significantly better than that of the sensitive group, P〈0.05;After 6 months of treatment,there was no significant difference in the therapeutic effect between the two groups, P〉0.05. Conclusion Children are not sensitive and albumin between Kawasaki disease closely, repeated by intravenous injection of gamma globulin combined with aspirin therapy can effectively improve the children with the disease.