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急性心肌梗死心肌保护策略研究进展 被引量:5

Current status of myocardial protection strategy in patients with acute myocardial infarction
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摘要 急性心肌梗死是目前威胁我国国民健康最主要的心血管疾病,梗死后早期有效的再灌注治疗则是减少心肌梗死面积和改善患者临床预后的有效措施.然而,再灌注本身也会带来额外的心肌结构及功能的损伤,忽视急性心肌梗死后心肌保护治疗往往会降低患者的临床获益.近年来,关注急性心肌梗死心肌保护成为研究热点,例如:缺血后适应,药物干预等,这对心肌梗死患者的救治有着深远的意义.因此,本研究对目前再灌注前、再灌注期、再灌注后的急性心肌梗死心肌保护策略以及相关研究进展予以总结阐述. AIM: In recent years, the number of patients with acute myocardial infarction (AMI) has gradually increased in our country. Reperfusion therapy during the early stage after infarction is a safe and effective therapeutic treatment for patients with AMI, which can reduce the infarction size and improve the prognosis of patients. However, reperfusion can also bring problems of its own, such as damage to the myocardial structure and function. One of the reasonable explanation for that may be the ignorance of myo- cardial protection treatment. Therefore, more and more researches focus on myocardial protection, such as ischemic postconditioning, drug intervention, etc. which are important to patients with myo- cardial infarction. Therefore, myocardial protection strategy and recent related research progress about AMI before reperfusion, reperfusion, after reperfusion are reviewed in this paper.
出处 《转化医学电子杂志》 2017年第3期17-21,共5页 E-Journal of Translational Medicine
基金 国家自然科学基金项目(81671763) 国家重点研发计划项目(2016YFC1301100)
关键词 急性心肌梗死 心肌保护 药物治疗 缺血后适应 acute myocardial infarction myocardial protection drug therapy ischemie postconditioning
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