贝那普利与卡托普利分别联合氨氯地平治疗原发性高血压疗效及安全性对比

Curative effect and safety comparison of benazepril and captopril respectively combined with amlodipine on primary hypertension

目的对比贝那普利与卡托普利分别联合氨氯地平治疗原发性高血压的疗效及安全性。方法采用前瞻性研究方法,选择2014年1月至2016年5月在我院诊治的原发性高血压患者80例作为研究对象,随机分为观察组与对照组,各40例。对照组采用卡托普利联合氨氯地平治疗,观察组采用贝那普利联合氨氯地平治疗,比较两组患者的治疗效果。结果治疗后,观察组患者的收缩压和舒张压分别为(116.36±10.85)mm Hg和(72.96±4.12)mm Hg,对照组的收缩压和舒张压分别为(131.44±11.74)mm Hg和(84.24±5.36)mm Hg,均低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前、后两组患者的血浆TC与LDL-C水平比较无明显差异(P>0.05)。结论相对于卡托普利联合氨氯地平,贝那普利联合氨氯地平治疗原发性高血压具有更好的疗效,且应用安全性较好,有很好的应用价值。

Objective To compare the curative effect and safety of benazepril and captopril respectively combined with amlodipine on primary hypertension. Methods Eighty cases of patients with primary hypertension diagnosed and treated in our hospital from January 2014 to May 2016 were selected as the study objects. All the patients were randomly divided into observation group and control group, with 40 cases in each group. The control group accepted eaptopril combined with amlodipine, while the observation group received benazepril combined with amlodipine. The clinical effects of the patients in two groups were compared. Results After treatment, the systolic blood pressure and diastolic blood pressure of the observation group were （116.36±10.85） mmHg and （72.96±4.12） mmHg respectively, which were significantly lower than （131.44±11.74） mmHg and （12.11±3.14） mmHg of the control group; meanwhile, the systolic blood pressure and diastolic blood pressure of the two groups were significantly lower than those before treatment, the differences were statistically significant （P〈0.05）. There were no statistical significanees in plasma TC and LDL-C levels of the two groups before and after treatment. Conclusion Compared with captopril combined with amlodipine, benazepril combined with amlodipine has better curative effect and safety in the treatment of primary hypertension, which has great application value.