达英-35联合二甲双胍治疗多囊卵巢综合征后促排卵效果观察

Effect observation of Diane-35 combined with metformin on ovulation induction after polycystic ovary syndrome

目的对达英-35联合二甲双胍治疗多囊卵巢综合征后促排卵效果进行观察。方法选择我院收治的多囊卵巢综合征患者120例,并随机分为观察组和对照组,每组60例。观察组患者采用达英-35联合二甲双胍进行治疗,对照组仅使用达英-35进行治疗,对两组患者在治疗后的性激素水平及促排卵结局等进行比较。结果治疗后,观察组患者周期取消率、卵巢过度刺激综合征(OHSS)发生率显著低于对照组,妊娠率显著高于对照组,差异有统计学意义(P<0.05);观察组患者的卵泡刺激素(FSH)、睾酮(T)、黄体生成素(LH)激素水平均低于对照组,差异有统计学意义(P<0.05)。结论使用达英-35联合二甲双胍治疗多囊卵巢综合征后,在促排卵方面取得了良好的效果,可使患者的激素水平、排卵情况得到有效改善,具有临床推广的价值。

Objective To observe the clinical effect of Diane-35 combined with metformin on ovulation induction after polycystic ovary syndrome. Methods One hundred and twenty cases of patients with polycystic ovary syndrome in our hospital were selected and randomly divided into observation group and control group, with 60 cases in each group. The observation group was treated with Diane-35 combined with metformin, while the control group was only treated with Diane-35 for treatment. The sex hormone levels and ovulation outcome and other aspects of the two groups were compared. Results After treatment, the cycle cancellation rate and ovarian hyperstimulation syndrome （OHSS） occurrence rate were significantly lower than those of the control group, the pregnancy rate was significantly higher than that of the control group （P〈0.05）. The levels of follicle stimulating hormone （FSH）, testosterone （T） and luteinizing hormone （LH） were lower than those of the control group （P〈0.05）. Conclusion Diane-35 combined with mefformin in patients with polycystic ovary syndrome can achieve good results in ovulation situation, improve the patient＇s hormone levels and ovulation situation effectively, which has clinical promotion value.