地屈孕酮与黄体酮治疗先兆流产疗效观察

Clinical effect observation of dydrogesterone and progesterone in the treatment of patients with threatened abortion

目的对比地屈孕酮与黄体酮用于治疗先兆流产的临床效果。方法选择我院收治的150例先兆流产患者为研究对象,其中75例患者采用地屈孕酮治疗,设定为地屈孕酮组,其余75例患者采用黄体酮治疗,设定为黄体酮组,对比两组患者的临床治疗效果。结果两组患者的腰酸缓解时间、腹痛缓解时间、止血时间比较,差异无统计学意义(P>0.05);治疗前,两组患者的人绒毛膜促性腺激素(HCG)、雌二醇(E2)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的HCG、E2水平均高于治疗前(P<0.05);两组患者的保胎成功率比较,差异无统计学意义(P>0.05);地屈孕酮组不良反应发生率为22.67%,明显低于黄体酮组的42.67%(P<0.05)。结论地屈孕酮与黄体酮用于治疗先兆流产临床效果显著,保胎效果良好,地屈孕酮不良反应发生率更低,临床应用价值更高。

Objective To compare the clinical effect of dydrogesterone and progesterone in the treatment of patients with threatened abortion. Methods One hundred and fifty cases of patients with threatened abortion admitted in our hospital were selected as the study objects. Seventy-five cases of patients were treated with dydrogesterone, which were chosen as the dydrogesterone group; the other 75 cases of patients accepted progesterone, which were chosen as the progesterone group. The clinical effects of two groups were compared. Results There were no significant differences on lumbar acid remission time, abdominal pain relief time and bleeding time of two groups （P〉0.05）. Before treatment, there were no significant differences on the levels of HCG and E2 of two groups （P〉0.05）. After treatment, the levels of HCG and E2 of two groups were better than those before the treatment （P〈0.05）; There was no significant difference on success rate of tocolytic of two groups （P〉0.05）. The incidence rate of adverse reactions of the dydrogesterone group was 22.67%, which was lower than 42.67% of the progesterone group （P〈0.05）. Conclusion Dydrogesterone and progesterone in the treatment of patients with threatened abortion have significant clinical effect, the tocolytic effect is good, but dydrogesterone has fewer adverse reactions and higher clinical value.