核因子-κB与动脉粥样硬化关系的研究进展

Research Progress of Nuclear Factor-κB in Atherosclerosis

动脉粥样硬化是包括心肌梗死在内的多种心血管疾病的病理基础,是全世界死亡的主要原因。炎症始终存在于动脉粥样硬化发生发展的各个阶段,核因子-κB是炎症反应中的一个主要转录因子,在静息状态下,以同源二聚体或异源二聚体的形式存在于胞质中,通过与抑制剂κB相互作用,保持未活化状态。一旦受到细胞外刺激,如应激、细胞因子和自由基等,核因子-κB与抑制剂κB解离并易位到细胞核中。活化的核因子-κB诱导大量基因转录,包括细胞因子、黏附分子、趋化因子和急性期蛋白等。许多核因子-κB的激活剂和核因子-κB调控的基因直接或间接地参与了动脉粥样硬化的过程。现总结核因子-κB与动脉粥样硬化关系的研究进展。

Atherosclerosis is the pathological basis of a variety of cardiovascular diseases ,including myocardial infarction ,and is the world＇s leading cause of death .Inflammation is always in every stage of atherosclerosis development .Nuclear factor-κB （ NF-κB） is a major transcription factor in inflammatory response .In the resting state ,homodimers or heterodimers are present in the cytoplasm and remain unacti-vated by interaction with an inhibitor of NF-κB （ IκB） .Once exposed to extracelllular stimuli ,such as stress ,cytokines and free radicals ,NF-κB and IκB dissociation and translocation to the nucleus .Activation of NF-κB induced a large number of gene transcription ,including cyto-kines,adhesion molecules ,chemokines and acute phase proteins .Many NF-κB activators and NF-κB-regulated genes directly or indirectly participate in the process of atherosclerosis .In this review,we summarize the progress of the role NF-κB in atherosclerosis.