神经前体细胞表达发育调控蛋白4与盐敏感性高血压

Neural Precursor Cell Expressed Developmentally Down-regulated 4-Like and Salt-sensitive Hypertension

原发性高血压是一种主要的心血管危险因素,其发病率高,并会导致一系列严重并发症。该病病因复杂,众多遗传和环境因素共同参与发病。与摄盐有关的高血压被称作盐敏感高血压,无关的则称为盐抵抗高血压,二者在基因水平上具有差异。神经前体细胞表达发育调控蛋白4(NEDD4L)可使上皮细胞钠通道被降解,从而参与血压调节。除去上皮细胞钠通道之外,NEDD4L还与其他肾脏钠通道的调节有关。因而可推知,NEDD4L与盐敏感性高血压密切相关,现对近年来这方面的研究证据进行综述。

Primary hypertension is a major cardiovascular risk, which has a high prevalence rate and can cause a series of severe complications. Its etiology is highly complicated with substantial genetic and environmental factors involved. Salt-sensitive hypertension is defined as blood pressure increase related with salt intake, which is regulated by hereditary genetics. Neuronal precursor cell expressed developmentally down regulated-like （NEDIML） can degrade the epithelial Na - channels （ENaC） and consequently participate in blood regulation. Additionally ENaC, NEDIML also interacts with other sodium channels in the kidney. Therefore, it is speculated that NED134L is tightly correlated with salt-sensitive hypertension. This article reviews the latest research in this field.