IBI评分对肝癌预后的价值

The Value of Inflammation Based Index in Hepatocellular Carcinoma Prognosistic Patient

目的:探讨基于炎症反应指数(inflammation based index,IBI)评分预测、判断肝癌(hepatocellular carcinoma,HCC)预后的价值。方法:选取2011年6月至2014年6月在本院肝胆外科手术治疗的119例HCC患者,按照IBI评分标准分为IBI 0分组(21例)、1分组(44例)和2分组(54例),观察IBI评分和HCC临床病理特征间的关系,并结合巴塞罗那(Barcelona Clinic Liver Cancer,BCLC)分期进行无瘤生存时间分析。结果:IBI评分异常增高组与IBI评分0分组的患者比较,血清AFP水平(P<0.05)和肝内转移发生例数(P<0.01)显著升高,肝功能Child-pugh分级(P<0.01)和BCLC分期(P<0.01)有显著差异。IBI评分0分、1分、2分者无瘤生存时间呈显著性递减关系(P<0.05);BCLC分期越晚,其无瘤生存时间越短(P<0.05)。结论:IBI评分与肝癌临床病理特征、BCLC分期具有一致性,可作为判断肝癌患者预后的有效指标。

Objective：To investigate the usefulness of the inflammation based index（IBI）as prognostic factors in patients with hepatocellular carcinoma（HCC）.Methods：A total of 119 HCC patients admitted in our hospital from July 2011 to July 2014 were enrolled in the study.The HCC patients were assigned according to the grade（0,1,2）of IBI.The correlations between IBI and clinic-pathologic features were detected in the study.The prognostic significance of IBC and barcelona clinic liver cancer（BCLC）were analyzed by univariate survival analysis.Results：The AFP level in human serum（P〈0.05）and inntrahepatic metastasis（P〈0.01）significantly increased in the HCC patients of the high IBI group compared with 0 grade IBI group.Child-Pugh class and BCLC had a significant difference between 0,1,2 IBI groups（P〈0.01）.The IBI grade negatively correlated with tumor-free survival time.Conclusion：The IBI score is consistent with the clinicopathological features and BCLC staging of HCC,which could be used as an effective indicator for the prognosis of HCC patients.