自由基反应在化工生产中的风险控制

Risk Control of Radical Reaction in Chemical Production

在工业化生产吡唑醚菌酯的工艺中,以邻硝基甲苯为原料,1,3-二溴-5,5-二甲基海因为溴化剂,AIBN为引发剂,生产中间体邻硝基苄基溴。由于对邻硝基甲苯进行溴化时是自由基反应,原料配比,溶剂种类,反应温度和反应时间对自由基活性都有影响。这种影响在生产中有可能发生不可控,对生产管理造成一定的安全风险。结合在生产过程中遇到的问题,对邻硝基甲苯溴化反应热进行估算,得到相关数据后对设备重新评估并改进,从而降低安全风险。

In the industrial production of pyraclostrobin process,the o-nitromethyl bromide could be synthesized by o-nitrotoluene as raw material,1,3-dibromo-5,5-dimethylhydantoin as bromination and AIBN as initiator. Since the onitrotoluene is a radical reaction when brominated,the ratio of raw material,solvent,reaction temperature and reaction time have influence on the radical. This effect may occur in the production of uncontrollable,leading to a certain security risk for the production management. The bromination reaction heat of o-nitrotoluene was estimated by combining with the problems encountered in the production process,and the relevant data were re-evaluated and improved to reduce the safety risk.