协同护理模式对溃疡性结肠炎患者IL-23、IL-17、心理及躯体状况的影响

Effects of synergistic nursing model on IL-23,IL-17 inflammatory factors and psychological and physical condition in patients with ulcerative colitis

目的观察协同护理模式对溃疡性结肠炎患者IL-23、IL-17炎症因子及心理和躯体状况的影响。方法选择2013年1月—2014年12月浙江医院溃疡性结肠炎患者88例分为观察组和对照组。2组患者根据病情不同给予治疗,对照组给予常规护理,观察组在常规护理的基础上给予协同护理模式,观察2组患者治疗前后外周血中IL-17、IL-23的表达,对2组患者进行健康调查简易量表(SF-36)、抑郁自评调查。结果与治疗前比较,观察组和对照组治疗后IL-17、IL-23较治疗前均明显下降(P<0.05);观察组治疗后上述指标下降程度高于对照组(P<0.05);与治疗前比较,观察组和对照组干预后生活质量总分、精神健康、社会功能、情感职能、精力、躯体疼痛、健康状况、生理职能和心理功能评分均升高(P<0.05);且观察组干预后均高于对照组干预后(P<0.05),治疗前2组生活质量评分比较差异无统计学意义(P>0.05)。与治疗前比较,观察组和对照组干预后抑郁自评评分均降低(P<0.05);观察组治疗后抑郁自评评分低于对照组(P<0.05),治疗前2组抑郁自评评分比较差异无统计学意义(P>0.05)。结论协同护理模式可有效结合治疗,改善患者外周IL-17、IL-23的表达,同时具有针对性,充分调动患者的主观能动性和积极性,参与自我行为的管理和健康的决策,提高患者的生存质量,降低抑郁的发生率,因此值得临床推广使用。

Objective To observe the effect of synergistic nursing model on IL-23 and IL-17 inflammatory factors and psychological and physical condition in patients with ulcerative colitis. Methods From January,2013 to December,2014,88 patients with ulcerative colitis in Zhejiang hospital were divided into observation group and control group. he patients in the two groups were given different treatments according to the different conditions. he control group was given routine nursing. he observation group was given the model of synergetic care on the basis of routine nursing. he IL-17 and IL-23 expression in the two groups were observed before and after the treatment,meanwhile two groups were given SF-36 and depression self-rating survey. Results Compared with those before treatment,the levels of IL-17 and IL-23 in the observation group and the control group decreased significantly after treatment（ P〈0. 05）. The decrease of the above indexes in the observation group was higher than that in the control group（ P〈0. 05）,Mental health,social function,emotional function,energy,physical pain,health status,physiological function and psychological function scores of the observation group and the control group were all higher than those before treatment（ P〈0. 05）. The score of quality of life,mental health,social function,emotional function,energy,physical pain,health status,physiological function and psychological function of the observation group were higher than those of the control group（ P〈0. 05） The difference was not statistically significant（ P〈0. 05）. In the observation group,the self-rating depression score of the treatment group was lower than that of the control group（ P〈0. 05）. Before the treatment,the self-rating score of the two groups was significantly lower than that of the control group. he difference was not statistically significant（ P〉0. 05）. Conclusion Collaborative nursing model can effectively improve the peripheral IL-17 and IL-23 expression in patients with acute pancreatitis. It is also targeted to fully mobilize the patient＇s initiative,participate in self-behavior management and health decision-making,improve the patient＇s quality of life,and reduce the incidence of depression,thus worthy of clinical use.