摘要
目的探讨脑膜瘤MRI显示瘤周水肿程度与肿瘤组织Ki-67表达水平的相关性。方法收集2013年1月至2016年1月经手术切除及病理组织学证实的脑膜瘤标本159例,采用免疫组织化学染色方法检测Ki-67的表达;术前头颅MRI评估瘤周水肿程度。结果 159例中,无瘤周水肿21例,Ⅰ度水肿60例,Ⅱ度水肿29例,Ⅲ度水肿49例;瘤周水肿发生率为86.8%(138/159)。脑膜瘤组织Ki-67阴性表达为108例,弱阳性为25例,阳性为11例,强阳性为15例。脑膜瘤瘤周水肿程度与肿瘤组织Ki-67表达水平呈正相关(rs=0.486;P<0.001)。结论术前影像学检查评估脑膜瘤瘤周水肿程度,可作为预测Ki-67的表达水平及肿瘤恶性程度的因素之一,可为临床制定合理的治疗方案及判断预后提供重要依据。
Abstract:Objective To analyze the correlativity between the level of Ki-67 expression and peritumorous brain edema (PTBE) in the patients with intracranial meningiomas. Methods The expression of Ki-67 was detected by immunohistochemical staining in 159 specimens of the intracranial meningiomas confirmed by histopathological examination from January, 2013 to January, 2016. The degree of PTBE was evaluated by preoperative MRI in all the patients with intracranial meningiomas serving as the above-mentioned specimens. The correlativity between the level of Ki-67 expression in the timorous tissues and PTBE was analyzed by statistical method. Results There was significant difference in the level of Ki-67 expression among the meningiomas tissues with different degrees of PTBE (P〈0.05). The levels of Ki-67 expression were positively correlated with the degree of PTBE (rs=0.486; P〈0.01). Conclusion It is suggested that the degree of PTBE evaluated by preoperative MRI may be used to predict the expression of Ki-67 and the grade of malignancy of meningiomas, thus providing a significant basis for proper therapy and prognositic prediction.
出处
《中国临床神经外科杂志》
2017年第3期168-170,共3页
Chinese Journal of Clinical Neurosurgery
基金
国家自然科学基金(81471855)
关键词
脑膜瘤
KI-67
瘤周水肿
相关性
Intracranial meningiomas
Ki-67
Expression
Peritumorous brain edema
Correlativity