胡萝卜酸乙酯的绿色合成工艺研究

Study on Green Synthesis Technology of Diethyl Malonate

以丙二酸和乙醇为原料,强酸性阳离子交换树脂为催化剂,合成出胡萝卜酸乙酯,通过单因素实验优化了反应工艺。实验结果表明:当无水乙醇与丙二酸的摩尔比3∶1、催化剂的使用量为丙二酸质量的60%、反应时间2.5 h、反应温度80℃时,胡萝卜酸乙酯的产率最高为78.42%;强酸性阳离子交换树脂催化能力在连续使用7次后开始明显下降,再次活化后催化性能保持良好。

The diethyl malonate was synthesized from malonate and ethanol by using strong-acid cation exchange resin as catalyst, and the conditions was optimized by single factor experiment. The results showed that when n（malonate） ： n（ethanol）= 1 ： 3, the amount of catalyst was 60% of malonate, reaction time was 2.5 h, the reaction temperature was 80℃, the yield of diethyl malonate was 78.42%. The catalyst losted activity after being used 7 times and had a good catalytic after activation.