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HMGB1在扁平苔藓皮损中的异常分布

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摘要 高迁移率族蛋白1(HMGB1)是体内细胞处于稳态时,普遍存在于哺乳动物细胞核内的非组蛋白染色体结合蛋白,主要参与基因调节和转录[3]。当外界有适当的信号刺激细胞时,HMGB1赖氨酸残基被乙酰化,然后释放到细胞外,参与炎症反应。已有研究表明HMGB1在各种炎症性和自身免疫性疾病如系统性红斑狼疮(SLE)、类风湿关节炎(RA)、寻常型银屑病(Psoriasis Vulgaris)、
出处 《中国实验诊断学》 2017年第3期488-490,共3页 Chinese Journal of Laboratory Diagnosis
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