偏头痛与卵圆孔未闭相关性分析及介入封堵术的疗效评价

Analysis of the correlation between migraine and patent foramen ovale and the evaluation of the curative effect of interventional closure

目的 探讨偏头痛与卵圆孔未闭的相关性,并分析卵圆孔介入封堵术治疗偏头痛的临床疗效。方法选取2015年1月~2016年10月之间我院收治的133例偏头痛患者,设为观察组,选取同期健康体检者245例作为对照组,对比两组受检者卵圆孔未闭率。选择卵圆孔未闭的偏头痛患者行介入封堵术治疗,对比患者治疗前后偏头痛的发作频次、持续时间、头痛程度等指标。结果观察组患者中卵圆孔未闭者44例,占33.1%,对照组患者中卵圆孔未闭者仅3例,占1.2%,两组差异有统计学意义(P<0.05);观察组患者中44例卵圆孔未闭者均实施卵圆孔介入封堵术治疗,治疗后患者的偏头痛发作频次、持续时间、头痛程度评分均显著低于治疗前,差异有统计学意义(P<0.05)。结论卵圆孔未闭可能与偏头痛的发生密切相关,合并卵圆孔未闭的偏头痛患者实施卵圆孔介入封堵术能够有效改善患者的临床症状,值得在临床上推广和应用。

Objective To explore the correlation between migraine and patent foramen ovale, and to analyze the clinical efficacy of interventional closure of oval foramen in the treatment of migraine. Methods A total of 133 migraine pa- tients who were admitted to our hospital from January 2015 to October 2016 were seleeted as the study subjects and were assigned to the observation group. 245 healthy subjects were selected as the control group. The rate of patent fora- men ovale was compared between the two groups. The migraine patients with patent foramen ovale were selected and were given interventional closure for treatment. The migraine attack frequency, duration, headache degree and other in- dicators were compared before and after the treatment. Results In the observation group, there were 44 patients with patent foramen ovale, accounting for 33.1%. There were only 3 patients with patent foramen ovale （1.2%） in the control group, and the difference was statistically significant （P〈0.05）; in the observation group, 44 patients with patent foramen ovale were all treated with interventional closure of oval foramen. After the treatment, the attack frequency of migraine, duration and headache degree were significantly lower than those before treatment, and the differences were statistically significant （P〈0.05）. Conclusion Patent foramen ovale may be closely related to the occurrence of migraine. The inter- ventional closure of oval foramen in the patients with migraine complicated with patent foramen ovale can effectively improve the clinical symptoms of patients, which is worthy of clinical promotion and application.