摘要
目的探讨冠心病患者血清mi RNA表达与糖代谢异常的相关性。方法选取我院心内科收治的45例患者为研究对象,分为对照组、冠心病组和合并组(糖尿病并冠心病),各15例。采用实时定量PCR技术对不同分组患者血清中mi R-126及mi R-146进行检测,比较三组患者的mi R-126及mi R-146表达水平。结果冠心病组及合并组患者较对照组mi R-126在体内的表达水平明显较高(P<0.05),mi R-146表达水平三组比较差异无统计学意义(P>0.05)。结论冠心病患者血清mi RNA表达水平与糖代谢异常的存在一定的相关性,血清mi RNA检测可在临床中作为指导糖尿病大血管病变诊断的参考依据。
Objective To study the correlation of the abnormal glucose metabolism and serum miRNA expression in patients with coronary heart disease. Methods Forty-five patients admitted in cardiovascular department in our hospital were divided into control group, coronary heart disease group and combination group（diabetes mellitus and coronary heart disease）, with 15 cases in each group. The expression levels of the serum mi R-126 and miR-146 of the three groups were detected by real-time quantitative PCR technique. The expression levels of the serum mi R-126 and miR-146 of the three groups were compared.Results The expression levels of the serum miR-126 of the coronary heart disease group and combination group were higher than those of the control group（P〈0.05）. There were no significant difference in the expression levels of the serum miR-146 of three groups（P〉0.05）. Conclusion There is certain correlation of the abnormal glucose metabolism and serum miRNA in patients with coronary heart disease. It can be used as a reference for the diagnosis of diabetic macrovascular disease in clinic.
出处
《临床医学研究与实践》
2017年第6期36-37,共2页
Clinical Research and Practice
