PCT、CRP和WBC在重症肺炎患者血清检测中的临床意义

The clinical value of PCT, CRP and WBC on patients with severe pneumonia

目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)和白细胞计数(WBC)在重症肺炎中的变化及其临床意义。方法随机抽取我院2014年1月至2015年6月收治的重症肺炎患者35例,根据预后分为存活组和死亡组,在患者入院的第1、4、7天和转科或死亡前分别检测血清PCT、CRP和外周WBC的变化。结果 35例重症肺炎死亡13例,存活22例,其中存活组在第4、7天和转出前血清PCT、CRP和外周WBC的水平明显低于死亡组,差异有统计学意义(P<0.05)。结论血清PCT、CRP和外周WBC在重症肺炎患者中的水平升高明显,特别表现在预后差的患者,上述指标的检测能有效帮助临床判断肺炎的病情程度、发展及预后,其中连续检测血清PCT的敏感性较高,临床指导意义更大。

Objective To investigate the clinical value of serum procalcitonin（PCT）, C-reactive protein（CRP） and white blood cell count（WBC） on patients with severe pneumonia. Methods Thirty-five cases of patients with severe pneumonia were selected from January 2014 to June 2015 in our hospital and divided into survival group and death group according to the prognosis. The changes of PCT, CRP and WBC were detected at 1, 4 and 7 day after admission or before transferred to another department or death. Results There were 13 cases of patients in death group and 22 cases of patients in survival group. At 4 and 7 day after admission and transferred, the value of PCT, CRP and WBC in survival group were obviously lower than those in death group, the differences were statistically significant（P〈0.05）. Conclusion The value of PCT, CRP and WBC were significantly higher in patients with severe pneumonia, especially in patients with poor prognosis. The detection of PCT, CRP and WBC can effectively help to judge the pneumonia severity, development and prognosis, and the continuous detecting of serum PCT can improve the sensitivity, which has greater clinical significance.