PI-IBS与NPI-IBS患者的临床对比研究

Clinical comparative study of patients with PI-IBS and NPI-IBS

目的探讨炎症诱导型肠易激综合征(PI-IBS)与非PI-IBS(NPI-IBS)患者的临床特征。方法选择2014年3月至2015年6月在该院接受治疗的肠易激综合征(IBS)患者93例。其中PI-IBS患者38例,NPI-IBS患者55例。比较两组患者血清炎症细胞因子水平、胃肠道积分和胃肠道功能的差异。结果 PI-IBS组患者C反应蛋白(CRP)及白细胞介素(IL)-18、IL-6水平明显高于NPI-IBS组(P<0.05);PI-IBS组患者促胃液素(GAS)、血管活性肽(VIP)和胃动素(MOT)水平明显低于NPI-IBS组(P<0.05);PI-IBS组患者肠鸣音积分、腹胀痛积分和胃肠反应积分明显高于NPI-IBS组(P<0.05);PI-IBS组患者生活质量各维度得分均低于NPI-IBS组(P<0.05)。结论 PI-IBS患者血清炎症细胞因子水平较高,且胃肠功能较NPI-IBS患者差,可作为临床鉴别指标。

Objective To observe the clinical characteristics in the patients with post infectious irritable bowel syndrome（PIIBS）and patients with non-PI-IBS（NPI-IBS）.Methods Ninety-three patients with irritable bowel syndrome（IBS）treated in our hospital from March 2014 to June 2015 were selected,including 38 cases of PI-IBS and 55 cases of NPI-IBS.The differences of serum inflammatory cytokines levels,gastrointestinal score and gastrointestinal function were compared between the two groups.Results The levels of CRP,IL-18 and IL-6in the PI-IBS group were significantly higher than those in the NPI-IBS group,and the difference was statistically significant（P〈0.05）;the level of GAS,VIP and MOT in the PI-IBS group were significantly lower than those in the NPI-IBS group,the difference was statistically significant（P〈0.05）;the bowel sounds score,abdominal distension and pain score and gastrointestinal reaction score in the PI-IBS group were obviously higher than those in the NPI-IBS group,the difference was statistical significance（P〈0.05）;the various dimensional scores of quality of life in the PI-IBS group were lower than those in the NPI-IBS group,and the difference was statistically significant（P〈0.05）.Conclusion The levels of serum inflammatory cytokines in PI-IBS patients are higher,moreover the gastrointestinal function is poorer than that in NPI-IBS patients,which can be the indicators of clinical differentiation.