臭氧与透明质酸治疗膝骨性关节炎安全性和有效性的Meta分析

Safety and effectiveness of ozone versus hyaluronic acid for treating knee osteoarthritis:a Meta analysis

目的运用Meta分析的方法,比较臭氧(O3)与透明质酸(HA)治疗膝骨性关节炎(KOA)的安全性和有效性。方法系统检索PubMed、Cochrane Library(2016年第1期)、Embase、CNKI、CBM、VIP、Wan-Fang数据库中相关临床随机对照试验(RCT),检索时限为各数据库建库至2016年1月23日。两名研究者独立筛选文献、提取数据,并行研究方法学质量评价。运用RevMan5.3和Stata13.0进行统计分析。结果纳入20个RCT,合计2 136例KOA患者。与HA治疗KOA比较,O3治疗有效率较高[比值比(OR)=2.78,P<0.01];缓解疼痛效果更佳[治疗后1、3、6个月:均数差(MD)=-0.25、-0.71、-1.70,均P<0.01]。二者并发症比较差异无统计学意义(OR=0.84,P=0.56)。结论当前证据显示O3对KOA近期疗效优于HA,安全性二者相当。

Objective To compare the safety and effectiveness between ozone（O3）and hyaluronic acid（HA）in treating knee osteoarthritis（KOA）by using the meta analysis method.Methods The relevant randomized controlled trials（RCTs）in PubMed,Cochrane Library（issue 1,2016）,Embase,CNKI,CBM,VIP,and Wan-Fang databases were retrieved from their establishment to January 23,2016.Two reviewers independently screened the literatures,extracted the data and evaluated the quality of the included RCTs.The results were performed the statistical analysis by using the RevMan5.3and Stata13.0software.ResultsTwenty RCTs involving 2 136 KOA patients were included.Compared with the HA treatment of KOA,the O3 treatment had higher treatment effective rate[odds ratio（OR）=2.78,P〈0.01],and better pain relief effect[at 1,3,6month after treatment：mean difference（MD）=-0.25,-0.71,-1.70,P〈0.01 ].There were no statistically significant differences in complications between the two treatment methods[OR=0.84,P=0.56].Conclusion Current evidences indicate that the short-term therapeutic effect of O3 for KOA is superior to HA,and the safety is similar.