摘要
目的:筛选出黎药裸花紫珠和胆木最佳药效组合,为开发新药做准备。方法:对裸花紫珠和胆木提取物的组合进行包括抗炎、镇痛、抗菌和解热等药效学研究。结果:裸花紫珠和胆木的水、醇提取物的单方和组方在剂量为0.52g/kg·bw时,对小鼠均有一定的抗炎、镇痛作用;剂量为0.4g/kg·bw时,两者单方对内毒素致热家兔具有解热作用;组方裸花紫珠醇提物-胆木醇提物(0.26g/kg:0.26g/kg)对内毒素致热家兔的解热效果更佳;两者的水、醇提取物单方和组方均有一定的抑菌作用。结论:组方裸花紫珠醇提物-胆木醇提物(0.26g/kg:0.26g/kg)的抗炎、镇痛、解热和抗菌等作用最佳。
Objective To filter out the best combination of Luohuazizhu and Danmu for the development of new drugs. Methods To study the anti - inflammatory, analgesic, antibacterial and antipyretic effects of the combination of Luohuazizhu and Danmu. Results The water / ethanol extract of Luohuazizhu or Danmu, the combination of Luohuazizhu and Danmu at the dose of 0. 52g/kg · bw, the mice have a certain anti - inflammatory, analgesic effect. At the dose of 0. 4g/kg · bw, the water / ethanol extract of Luohuazizhu or Danmu has anti - pyretie effect on endotoxin - induced heat rabbits, the effect of the ethanol extract of Luohuazizhu and Danmu the bark extract ( 1 : 1 ) were better. The water / ethanol extract of Luohuazizhu or Danmu, the combination of Luohuazizhu and Danmu, all of them have a certain baeteriostatic effect. Conclusion The anti - inflammatory, analgesic, antipyretic and antimicrobial effects of the ethanol extract of Luohuazizhu and Danmu the bark extract ( 1 : 1 ) were the best.
作者
高香奇
李诚丛
周星
GAO Xiangqi LI Chengcong ZHOU Xing(Pharmaceutical Institute of Hainan Province, Haikou 570311, China)
出处
《中国民族民间医药》
2017年第6期34-38,共5页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
2009年海南省科学事业费项目
关键词
黎药
裸花紫珠
胆木
最佳组合
药效学
Hainan Li - nationality Herbal
Luohuazizhu
Danmu
The Best Combination
Pharmacodynamics