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抗痛风药Lesinurad的专利技术分析

Analysis of the Patent about Lesinurad
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摘要 Lesinurad是全球首个尿酸盐重吸收转运因子(URAT1)抑制剂,临床用于治疗痛风,本文以全球范围内的专利申请数据为分析样本,对Lesinurad的相关专利进行分析,总结该领域的专利申请现状和研究进展,为我国医药企业对于该药物的研究提供建议。 Lesinurad is new Urate transporter 1（URAT1）. It uses for treating gout. The article analyzes the patent about Lesinurad, from the patent application over the world,in order to learn the development in the field and patent application status,and make recommendations for pharmaceutical companies.
作者 陆皞然 马彦冬 陈雪梅
机构地区 国家知识产权局专利局专利审查协作天津中心化学部
出处 《广东化工》 CAS 2017年第5期129-130,共2页 Guangdong Chemical Industry
关键词 Lesinurad 专利 分析 Lesinurad patent analysis
分类号 TQ [化学工程]
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参考文献4

二级参考文献55

  • 1Michael D, Jansen T L, George N, et al. Gout: why is this curable disease so seldom cured [J]. Ann Rheum Dis, 2012, 71(11): 1765-1770.
  • 2Pema K M. lesinuard sodium [J]. Drugs Fut, 2011, 36(12): 875.
  • 3Yeh L, Hingorani V, Manhard K, et al. Safety and uric acid lowering effect in humans following multiple doses of RDEA806, a novel prodrug for the potential treatment of hyperuricemia [J]. Ann Rheum Dis, 2008, 67: 248.
  • 4Yeh L, Tamai I, Hamatake R, et al. Mode of action of RDEA594 as a uric acid lowering agent in humans following multiple doses of its prodrug RDEA806 [J]. Ann Rheum Dis, 2008, 67(Suppl Ⅱ): 249.
  • 5Enomoto A, Kimura H, Chairoungdu A, et al. Molecular identification of a renal urate anion exchanger thatregulates blood urate levels [J]. Nature, 2002, 17: 447-452.
  • 6Endou H, Anzai N. Urate transport across the apical membrane of renal proximal tubules [J]. Nucleosides Nucleotides Nucleic Acids, 2008, 27(6): 578-584.
  • 7Hagos Y, Stein D, Ugele B, et al. Human renal organic anion transporter 4 operates as an asymmetric urate transporter [J]. JAm Soc Nephrol, 2007, 18(2): 430-439.
  • 8Yeh L T, Shen Z, Kerr B, et al. RDEA594, a potent URAT1 inhibitor without affecting other important renal transporters OAT1 and OAT3 [J]. Ann Rheum Dis, 2009, 68(Supp13): 320.
  • 9Yang X Q, Dick R, Borges V, et al. Evaluation of drug-drug interaction potential between RDEA594, allopurinol and febuxostat in preclinicalspecies [J]. Arthritis Rheum, 2009, 60: 412-413.
  • 10Yeh L, Yang J, Theiss J, et al. RDEA594, a potential uric acid lowering agent through inhibition of uric acid reuptake, shows better pharmacokinetics than its prodrug RDEA806 [C]. San Francisco: 2008 Annual Scientific Meeting, 2008.

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广东化工
2017年 第5期

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