分级心理护理对胃食管反流病患者焦虑、抑郁及血浆5-羟色胺、甘丙肽水平的影响

Influence of hierarchical psychological nursing on anxiety, depression, 5-HT and GAL of gastroesophageai reflux disease patients

目的探讨分级心理护理对胃食管反流病患者焦虑、抑郁及血浆5-羟色胺（5-HT）、甘丙肽（GAL）的影响。方法选择胃食管反流病患者238例，按照随机数字表法随机分为研究组与对照组，各119例，两组患者在相同的常规护理基础上，对照组给予常规心理护理，研究组给予分级心理护理。采用焦虑自评量表（SAS）、抑郁自评量表（SDS）评价两组患者不同心理护理方法前后的心理状况；同时用酶联免疫吸附法（ELISA）评价两组患者干预前后血浆5-羟色胺（5-HT）、甘丙肽（GAL）含量。结果分级心理护理4周后，研究组患者SAS评分和SDS评分分别为（41.47±9.37）,（42.13±12.36）分，对照组分别为（45.68±14.81）,（48.15±14.21）分，差异有统计学意义（t值分别为2.62，3.49；P〈0.05）。干预4周后，研究组患者血浆5-HT、GAL含量分别是（166.05±63.66）ng/ml、（23.18±8.74）pg/ml，对照组为（146.30±63.75）ng/ml、（25.45±9.03）pg/ml，差异有统计学意义（t值分别为2.39，1.97；P〈0.05）。结论分级心理护理能够改善胃食管反流病患者的焦虑、抑郁症状，使血浆5-HT、GAL的含量逐渐恢复正常水平，值得临床推广和普及。

Objective To study the influence of hierarchical psychological nursing on anxiety, depression, 5-hydroxytryptamine （5-HT） and Galanin （GAL） of patients with gastroesophageal reflux disease. Methods A total of 238 gastroesophageal reflux disease patients were divided into study group （n = 119） and control group（ n= 119） by random number table. Two groups of patients were given the same routine care. Based on this, patients in the control group were given conventional psychological nursing, the study group were given hierarchical psychological nursing. SAS and SDS were used to evaluate the two group patients mental status before and after different mental care. Enzyme linked immunosorbent assay （ELISA） was used to evaluate the contents of 5-HT and GAL of the two groups.Results After 4 weeks of hierarchical psychological nursing, SAS and SDS scores of the study group were （41.47±9.37） and （42.13±12.36）. Those scores of the control group were （45.68±14.81） and （48.15±14.21）. The differences were significant （t=2.62,3.49;P〈0.05）. After 4 weeks of hierarchical psychological nursing, 5-HT and GAL contents of the study group were （166.05±63.66） ng/ml and （23.18±8.74）pg/ml. Those contents of the control group were （146.30±63.75）ng/ml and （25.45± 9.03 ） pg/M. The differences were significant （ t = 2.39,1.97 ; P〈 0. 05 ）. Conclusions Hierarchical psychological nursing can decrease anxiety and depression of patients with gastroesophageal reflux disease and help the contents of GAL and 5-HT return to normal level gradually. It is worthy of clinical promotion and popularization.