硒催化羰基化合成乙霉威的研究

Study on selenium-catalyzed carbonylation to diethofencarb

以1,2-二乙氧基苯为起始原料,首先经硝化制得3,4-二乙氧基硝基苯。然后再以廉价易得的非金属硒作催化剂,一氧化碳作羰基化试剂,在优化条件下,经硒催化3,4-二乙氧基硝基苯与异丙醇的氧化还原羰基化反应可以65%的分离收率得到目标产物。与乙霉威的传统合成方法相比,该方法具有路线简短、操作简单、原子经济性高、成本低、环境相对友好等优点。

1,2-Diethoxy-4-nitrobenzene was firstly prepared by the nitration of 1,2-diethoxybenzene.Then,with cheap and easily available nonmetal selenium as catalyst,carbon monoxide as carbonylation reagent,the target product could be obtained in 65% yield via selenium-catalyzed redox carbonylation of 1,2-diethoxy-4-nitrobenzene with isopropanol under the optimal reaction conditions.Compared with the traditional approach to diethofencarb,this method had many advantages such as short synthetic route,simple operation,high atom economy,low cost and environmentally benign approach.