摘要
目的探讨分析肺结核诊断中联合应用血清腺苷脱氨酶(ADA)以及结核感染T细胞斑点试验(T-spot.TB)检测的临床价值。方法随机选取该院2015年1月—2016年10月收治的140例拟诊为肺结核患者分为治疗组(肺结核患者,70例)和对照组(非肺结核健康者,70例),对比两组ADA水平以及T-spot.TB阳性率以及联合检测的灵敏度、特异性等情况。结果治疗组患者ADA水平显著高于对照组(P<0.05),治疗组患者ADA检测阳性率(55.7%)、T-spot.TB阳性率(88.6%)显著高于对照组(15.7%、17.1%)。血清ADA、T-spot.TB平行联合检测可提高对肺结核诊断灵敏度(91.6%)及阴性预测值(93.6%),但阳性预测值、特异性明显下降,系列联合检测可提高对肺结核诊断的特异性(94.9%)、阳性预测值(86.2%),但是灵敏度、阴性预测值较低。结论肺结核患者采用血清ADA水平以及T-spot.TB斑点数联合检测的临床价值较高,值得推荐。
Objective To discuss the clinical value of combined test of serum ADA level and T-spot.TB in the diagnosis of pulmonary tuberculosis. Methods 140 cases of patients with pulmonary tuberculosis admitted and treated in our hospital from January 2015 to October 2016 were randomly selected and divided into the treatment group（patients with pulmonary tuberculosis, 70 cases） and the control group（patients with non-pulmonary tuberculosis, 70 cases）, and the ADA level, Tspot.TB positive rate and sensitivity and specificity of the combined test were compared between the two groups. Results The ADA level in the treatment group was obviously higher than that in the control group（P〈0.05）, the ADA test positive rate and T-spot.TB positive rate in the treatment group were obviously higher than those in the control group（55.7%, 88.6%vs 15.7%, 17.1%）, and the parallel combined test of serum ADA and T-spot.TB could improve the diagnosis sensitivity（91.6%） and negative predictive value（93.6%） of patients, but the positive predictive value and specificity obviously decreased, and the serial combined test can improve the specificity（94.9%） and positive predictive value（86.2%）, but the value was lower. Conclusion The clinical value of combined test of serum ADA level and T-spot.TB spot number for patients with pulmonary tuberculosis is higher, which is worth recommendation.
出处
《中外医疗》
2017年第4期38-40,共3页
China & Foreign Medical Treatment
