儿童社区获得性金黄色葡萄球菌肺炎的临床研究

Clinical Research on Children Community Acquired Staphylococcus Aureus Pneumonia

目的探讨儿童社区获得性金黄色葡萄球菌肺炎的临床特征。方法回顾分析该院2013年1月—2015年12月收治的160例儿童社区获得性金黄色葡萄球菌肺炎患儿的临床资料,对其临床特征进行总结。结果 160例儿童社区获得性金黄色葡萄球菌肺炎患儿中:男性98例,女性62例,男女比例1.56:1;6月以内患儿112例,占70.0%;冬春季发病多,占75.0%;有咳嗽134例、吐奶125例;青霉素耐药患儿141例、占88.0%,红霉素耐药患儿84例、占52.5%,克林霉素耐药患儿80例、占50.0%,苯唑西林耐药患儿34例、占21.0%;对万古霉素、替加环素、替考拉林、利奈唑胺均敏感。结论儿童社区获得性金黄色葡萄球菌肺炎发病者多见于6月龄以内小婴儿,冬春季发病多,以咳嗽、吐奶、发热为主要表现,普遍对青霉素、红霉素、克林霉素耐药,对万古霉素、替加环素、替考拉林敏感。

Objective To discuss the clinical features of community acquired staphylococcus aureus pneumonia. Methods The clinical data of 160 cases of children with community acquired staphylococcus aureus pneumonia admitted and treated in our hospital from January 2013 to December 2015 were retrospectively analyzed, and the clinical features were summarized. Results In the 160 cases, there were 98 male cases and 62 female cases, and the ratio was 1.56：1, and there were 112 cases of children within 6 months, accounting for 70.0%, and the morbidity in winter and spring was the most, accounting for 75.0%, and there were 134 cases with cough and 125 cases with vomiting milk, and there were 141 penicillin resistance cases, accounting for88.0%, erythromycin resistance cases, oxazocillineaccounting for 52.5%, 80 clindamycin resistance cases, accounting for 50.0%,34 oxazocilline cases, accounting for 21.0%, and all were sensitive to vancomycin, teicoplanin and linezolid for forest and linezolid. Conclusion Community acquired staphylococcus aureus pneumonia is mostly in infants within 6 months, and the incidence rate in winter and spring is more, cough, vomiting milk and fever are the main manifestations, generally, it is resistant to penicillin, erythromycin and clindamycin and sensitive to vancomycin, tygacil and teicoplanin.