探讨埃索美拉唑联合莫沙必利治疗胃食管反流性咳嗽的临床疗效评价

To Investigate the Evaluation of Clinical Efficacy of Esomeprazole Combined with Mosapride in Treatment of Gastroesophageal Reflux Cough

目的探讨埃索美拉唑联合莫沙必利治疗胃食管反流性咳嗽的临床疗效评价。方法随机选取2015年9月—2016年9月在该院内科门诊治疗的90例胃食管反流性咳嗽患者,随机分为两组,对照组单用埃索美拉唑治疗,观察组采用埃索美拉唑联合莫沙必利治疗,2个疗程后比较两组患者的临床疗效、各症状改善评分、不良反应。结果观察组咳嗽治疗有效率为95.56%,而对照组的为80.00%,观察组明显较高,两组间差异有统计学意义(P<0.05);观察组胃食管反流病治疗有效率为93.33%,与对照组的77.78%相比,明显较高(P<0.05);观察组治疗后咳嗽、反酸、烧心、胸骨后疼痛、总症状评分较对照组明显降低,差异有统计学意义(P<0.05);两组均出现不同程度的头晕、食欲减退、腹胀等不良反应,差异无统计学意义(P>0.05)。结论埃索美拉唑联合莫沙必利治疗胃食管反流性咳嗽疗效显著,能有效抑制胃酸分泌,促进胃肠动力,快速减轻咳嗽症状,减少复发,具有积极的临床意义。

Objective To investigate the clinical efficacy evaluation of esomeprazole combined with mosapride in treatment of gastroesophageal reflux cough. Methods Random selection September 2015-2016 year in September in my hospital outpatient treatment of 90 cases of gastroesophageal reflux cough patients were randomly divided into two groups, control group was treated with esomeprazole treatment, observation group used esomeprazole combined with Mosapride, treatment effect of two groups were compared after 2 courses of treatment, improvement of symptoms and adverse reactions. Results In the observation group, cough treatment effective rate of 95.56%, significantly higher than the control group 80.00%, the difference was statistically significant（P〈0.05）; the observation group is effective in the treatment of gastroesophageal reflux disease the rate was 93.33%, significantly higher than the control group 77.78%, the difference was statistically significant（P〈0.05）; the observation group after the treatment of cough, regurgitation, heartburn, chest pain and other individual symptom scores and total score were significantly lower than the control group, difference Difference was statistically significant（P〈0.05）; the two groups have different degrees of dizziness, anorexia, abdominal distension and other adverse reactions, no significant difference（P〉0.05）. Conclusion Esomeprazole combined with mosapride in treatment of gastroesophageal reflux cough has obvious curative effect, can effectively inhibit the secretion of gastric acid, promote gastrointestinal motility fast, relieve cough symptoms, reduce recurrence, has positive clinical significance.