异甘草酸镁治疗抗结核药引起的药物性肝炎临床疗效分析

Analysis of Clinical Curative Effect of Magnesium Isoglycyrrhizinate in Treatment of Drug Hepatitis Caused by the Antitubercular Agents

目的探讨异甘草酸镁治疗抗结核药引起的药物性肝炎的疗效。方法随机将方便选取2012年1月—2016年12月该院收治的61例抗结核药所致药物性肝炎患者分为两组。实验组31例,患者用药异甘草酸镁;对照组30例,患者复方甘草酸单铵S。观察两组疗效。结果治疗后,实验组患者肝功能指标ALT、AST、γ-GT和ALP的改善效果均优于对照组,治疗总有效率(96.8%)也明显高于对照组(80.0%),差异有统计学意义(P<0.05)。实验组用药不良反应发生率(0.0%)与对照组(3.3%)比较差异无统计学意义(P>0.05)。结论异甘草酸镁具有降酶护肝的作用,以此治疗抗结核药引起的药物性肝炎疗效确切,安全可靠,值得临床推广使用。

Objective To discuss the curative effect of magnesium isoglycyrrhizinate in treatment of drug hepatitis caused by the antitubercular agents. Methods Convenient selection 61 cases of patients with drug hepatitis caused by the antitubercular agents in our hospital from January 2012 to December 2016 were randomly divided into two groups with 31 cases in each, the experimental group were treated with isoglycyrrhizinate, while the control group were treated with Compound ammonium glycyrrhetate, and the curative effect of the two groups was observed. Results After treatment, the liver function indexes ALT, AST, γ-GT and ALP improvement effect was better than those in the control group, and the total treatment effective rate in the experimental group was obviously better than that in the control group（96.8% vs 80.0%）, and the difference had statistical significance（P〈0.05）, and the difference in the incidence rate of medication adverse reactions between the experimental group and the control group had no statistical significance（0.0% vs 3.3%）（P〉0.05）. Conclusion Isoglycyrrhizinate has the effect of reducing serum lipid andenzymes, and the curative effect of it in treatment of drug hepatitis caused by the antitubercular agents is definite, and it is safe and reliable, which is worth clinical promotion and application.