十味龙胆花颗粒对痰热蕴肺型老年急性支气管炎患者血清炎症因子、免疫功能的影响

Effect of Shiwei Longdanhua particles on serum inflammatory factors and immune function in elderly patients with acute bronchitis

目的 观察十味龙胆花颗粒对痰热蕴肺型老年急性支气管炎患者血清炎症因子、免疫功能的影响。方法 选取2014年11月~2016年10月台州市中医院收治的120例老年急性支气管炎患者,依据纳入顺序单双号随机分为观察组和对照组,每组各60例。对照组给予常规西医治疗,观察组在对照组的基础上给予十味龙胆花颗粒。治疗7d,观察2组血清炎症因子[超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）及白介素-6（IL-6）及白介素-1（IL-1）]及免疫功能指标的变化（CD3^＋、CD4^＋、CD8^＋、CD4^＋/CD8^＋以及IgM、IgG、IgA）。结果 治疗后,2组子hs-CRP、TNF-α及IL-6及IL-1较本组治疗前均显著下降,差异有统计学意义（P〈0.05）,且观察组各指标降幅大于对照组,比较差异均有统计学意义（P〈0.05）;治疗后,观察组CD3^＋、CD4^＋、CD4^＋/CD8^＋较本组治疗前明显升高而CD8^＋明显下降,差异有统计学意义（P〈0.05）,对照组与治疗前比较无明显差异,2组治疗后比较差异有统计学意义（P〈0.05）;治疗后,2组IgM、IgG、IgA均较本组治疗前明显下降,差异有统计学意义（P〈0.05）,且观察组各指标下降大于对照组,比较差异均有统计学意义（P〈0.05）。结论 十味龙胆花颗粒治疗老年急性支气管炎,有抑制炎症反应及改善免疫状态的作用。

Objective To observe the effect on serum inflammatory factors and immune function of Shiwei Longdanhua particles in elderly patients with acute bronchitis.Methods 120 cases of elderly patients with acute bronchitis from November 2014 to October 2016 were selected and randomly divided into the observation group and the control group with 60 cases in each group, according the order of single and double number.The control group was given conventional treatment, and the observation group was given Shiwei Longdanhua particles based on the control group.Treatment for seven days, to observe the differences of serum inflammatory factors （hs-CRP, TNF-αand IL-6, IL-1） and immunologic function indexes （CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋and IgM, IgG, IgA） between the two groups.Results After treatment, hs-CRP, TNF-αand IL-6, IL-1 of the two groups decreased with before treatment, the difference was statistically significant （P〈0.05）, and all indexes of the observation group were lower than those of the control group, the difference was statistically significant （ P〈0.05 ） .After treatment, CD3^＋, CD4^＋, CD4^＋/CD8^＋ of the two groups increased with before treatment except CD8^＋decreased, the difference was statistically significant （P〈0.05）, there was no significant difference between the control group and before treatment, there was significant difference between the two groups after treatment （P〈0.05）.After treatment, IgM, IgG and IgA of the two groups decreased with before treatment, the difference was statistically significant （P〈0.05）, and all indexes of the observation group were lower than those of the control group, with significant differences, the difference was statistically significant （P〈0.05）.Conclusion Shiwei Longdanhua particles has the effects of inhibiting inflammatory reaction and improving the immune status in the treatment of elderly patients with acute bronchitis .