扶正消癌方联合他莫昔芬对乳腺癌术后患者血清性激素及子宫内膜厚度的影响研究

Effects of Fuzheng Xiaoai decoction joint tamoxifen on serum sex hormone and endometrial thickness with breast cancer

目的 分析扶正消癌方联合他莫昔芬对乳腺癌术后患者血清性激素及子宫内膜厚度的影响,以探索乳腺癌患者术后理想药物治疗方案。方法 选取2012年1月～2015年9月于嘉兴市第二医院乳腺外科就诊的124例乳腺癌患者,随机分为对照组与研究组,每组62例,2组均予以相同手术治疗,对照组术后予以他莫昔芬治疗,研究组基于对照组加用扶正消癌方治疗,比较2组性激素、子宫内膜厚度、肿瘤标志物、免疫功能和并发症情况。结果 研究组催乳素（PRL）、孕酮（P）、雌二醇（E2）均低于对照组,比较差异有统计学意义（P〈0.05）。研究组子宫内膜厚度[（8.61±1.07）mm]低于对照组[（9.74±1.21）mm]（P〈0.05）。研究组肿瘤标志物、免疫功能优于对照组（P〈0.05）。2组并发症比较差异无统计学意义。结论 扶正消癌方联合他莫昔芬可调节血清性激素水平,缓解他莫昔芬所致子宫内膜增厚,且可降低肿瘤标志物水平及改善免疫功能,是较理想的乳腺癌患者术后药物治疗方案。

Objective To analyze the effects of Fuzheng Xiaoai decoction joint tamoxifen on serum sex hormone and endometrial thickness with breast cancer.Methods 124 patients with breast cancer were divided into control group and research group by lot drawing method, all as 62 cases, treated with the same surgery, control group was treated with tamoxifen, research group was treated with Fuzheng Xiaoai decoction based on control group, the sex hormones, endometrial thickness, tumor markers, immune function and complications were compared between two groups.Results The prolactin （PRL）, progesterone （P）, estradiol （E2） of research group were all lower than control group, the difference were statistically significant （P〈0.05）.The endometrial thickness of research group [（8.61＋1.07） mm]was lower than the control group [（9.74＋1.21） mm]（P〈0.05）.The tumor markers, immune function of research group were better than that of control group （P〈0.05）.The complications was no difference between two groups. Conclusion Fuzheng Xiaoai decoction joint tamoxifen can regulation the serum levels of sex hormone, relieve tamoxifen-induced endometrial thickening, can improve tumor markers and immune function .