醒脑静注射液对急性脑梗死患者认知功能恢复的影响

Effect of Xingnaojing injection on cognitive function recovery in acute cerebral infarction

目的 探讨醒脑静注射液对急性脑梗死患者认知功能恢复的效果。方法 选取2015年11月～2016年10月于浙江省玉环县中医院住院治疗的100例脑梗死患者,按照随机数字表法分为实验组与对照组,每组各50例。对照组给予常规的神经内科脑梗死治疗方案,包括静脉点滴活血治疗、静脉点滴甘露醇降低颅内压、皮下注射低分子肝素钠抗凝、控制血压血糖等至合适水平、预防静脉血栓等治疗及护理。实验组在对照组的基础上给予静脉点滴醒脑静注射液治疗,据病情适度调整剂量与滴速。入院时及治疗1月后分别应用蒙特利尔认知评估量表（Montreal cognitive assessment,Mo CA）及简易精神状态检查量表（minimum mental state examination,MMSE）进行认知功能的评定。结果 1月后实验组与对照组的Mo CA评分分别为（27.44±2.97）、（25.08±0.54）,较治疗前均有升高,但实验组升高较对照组明显,差异具有统计学意义（P〈0.05）;实验组与对照组的MMSE评分分别为（21.06±1.43）、（20.29±1.16）,较治疗前均未改变,差异无统计学意义。结论 醒脑静注射液可以改善急性脑梗死患者的认知损伤,Mo CA可以较MMSE更好的评估脑梗死患者的认知情况。

Objective To explore the effect of Xingnaojing injection on cognitive function recovery in patients with acute cerebral infarction. Methods 100 patients with cerebral infarction who were hospitalized from November 2015 to October 2016 were selected and randomly divided into experimental group and control group, with 50 cases in each group.The patients in the control group were treated with routine treatment of cerebral infarction, including treatment of blood circulation, intravenous drip of mannitol to reduce intracranial pressure, subcutaneous injection of low molecular weight heparin sodium anticoagulant, control of blood pressure and blood glucose to appropriate level, and prevention of venous thrombosis.On the basis of the control group, the experimental group received Xingnaojing injection treatment , according to moderate moderation dose and drip rate.We adjusted the dosage and the drop rate according to the illness.The cognitive function was assessed by using Montreal Cognitive Assessment Scale （ MoCA） and minimum mental state examination （MMSE） at admission and after one month of treatment.Results At one month after treatment, the MoCA score of the experimental group and the control group was （27.44 ±2.97）, （25.08 ±0.54） respectively, which was higher than that before treatment, but the experimental group was significantly higher than the control group, the difference was statistically significant （ P〈0.05 ） .The MMSE scores of the experimental group and the control group were （21.06 ±1.43）, （20.29 ±1.16） respectively, the score did not changed compared with before treatment, and the difference was not statistically significant.Conclusion Xingnaojing injection can improve cognitive impairment in patients with acute cerebral infarction, MoCA is better than MMSE in assessmenting the cerebral infarction patients cognitive situation.