胸腺肽α1联合血必净注射液对重症肺炎合并脓毒症患者血清CRP、TNF-α、IL-6、IL-8水平的影响

Effect of thymosin α1 combined with Xuebijing injection on serum CRP, TNF-α, IL-6 and IL-8 levels in severe pneumonia complicated with sepsis

目的 探讨胸腺肽α1联合血必净注射液对重症肺炎合并脓毒症患者血清CRP、TNF-α、IL-6、IL-8水平的影响,以探析治疗重症肺炎合并脓毒症患者的理想方案。方法 选择2014年9月～2016年8月安吉县第三人民医院治疗的77例重症肺炎合并脓毒症患者作为研究对象,按照抛硬币法将其为观察组（n=39）和对照组（n=38）,2组患者均给予早期积极抗感染、营养支持及液体复苏等综合性治疗,另外对照组患者以静脉滴注的方式注入50 mL血必净注射液,而观察组在此基础之上将1.6 mg胸腺肽α1进行皮下注射,比较2组患者CRP、TNF-α、IL-6、IL-8等炎症因子水平变化情况,并对临床效果进行综合分析。结果 治疗前,2组患者血清中的CRP、TNF-α、IL-6及IL-8水平值比较差异无统计学意义;治疗后,观察组患者血清中CRP、TNF-α、IL-6和IL-8水平值均显著低于对照组（P〈0.05）。观察组患者的临床总有效率（84.6%）明显大于对照组（57.9%）,2组差异具有统计学意义（P〈0.05）。结论胸腺肽α1联合血必净注射液治疗重症肺炎合并脓毒症能有效降低患者CRP、TNF-α、IL-6和IL-8水平,临床效果显著。

Objective To study the effect of thymosin α1 combined with Xuebijing injection on the levels of serum CRP, TNF-α, IL-6 and IL-8 in severe pneumonia complicated with sepsis.Methods 77 severe sepsis patients with sepsis from September 2014 to August 2016 were enrolled in the study.They were divided into observation group （n=39） and control group （n=38） .Patients were given early active anti-infection, nutritional support and liquid resuscitation and other comprehensive treatment, while the control group of patients with intravenous infusion of 50 mL Xuebijing injection, while the observation group with 1.6 mg thymosinα1 subcutaneous injection on the basis of control group.The levels of CRP, TNF-α, IL-6 and IL-8 were compared between the two groups, and the clinical effect was analyzed comprehensively .Results There was no significant difference in the levels of CRP, TNF-α, IL-6 and IL-8 between the two groups before treatment.After treatment, the levels of CRP, TNF-α, IL-6 and IL-8 levels in the treatment group were significantly lower than those in the control group （P〈0.05）.The total effective rate of the observation group （84.6%） was significantly higher than that of the control group （ 57.9%） , the difference was statistically significant （ P〈0.05 ） .Conclusion Thymosin α1 combined with Xuebijing injection in treatment of severe pneumonia with sepsis is effective, can decrease the CRP, TNF-α, IL-6 and IL-8 levels of patient.