加用红花黄色素对宫外孕保守治疗患者血浆D-D、β-HCG水平的影响

Effects of safflower yellow pigment on plasma D-D and β-HCG levels in patients with conservative treatment of ectopic pregnancy

目的 探讨加用红花黄色素对宫外孕保守治疗患者血浆D-聚体（D-D）、β人绒毛膜促性腺激素（β-HCG）水平的影响。方法 选择2014年4月～2016年4月于宁波市中医院行宫外孕保守治疗患者96例,参照抽签法分为对照组和实验组,各48例,对照组采用常规治疗,实验组在对照组基础上加用红花黄色素治疗,比较2组治疗效果、盆腔包块消失时间、D-D、β-HCG、血管内皮生长因子（VEGF）、糖类抗原125（CA125）及安全性。结果 实验组总有效率（97.91%）显著高于对照组（83.33%）,差异有统计学意义（P〈0.05）。实验组盆腔包块消失时间短于对照组（P〈0.05）;实验组D-D、β-HCG水平显著低于对照组（P〈0.05）;实验组VEGF、CA125低于对照组（P〈0.05）。2组治疗期间均未出现严重不良反应。结论 常规疗法加用红花黄色素在宫外孕保守治疗中可促进盆腔包块的吸收,降低血浆D-D、β-HCG水平,效果确切。

Objective To investigate the effect of safflower yellow pigment on plasma D-dimer （D-D） and β-human chorionic gonadotropin （β-HCG） in ectopic pregnancy patients.Methods 96 patients with conservative treatment of ectopic pregnancy from April 2014 to April 2016 in our hospital were divided into control group and experimental group according to the method of drawing lots.The control group was treated with routine therapy, the experimental group was treated with safflower yellow pigment based on the control group.Pelvic mass disappearance time, D-D, β-HCG, vascular endothelial growth factor, carbohydrate antigen 125 and safety of the two groups were compared.Results The total effective rate of the experimental group（97.91%） was higher than that of the control group（83.33%）,the difference was statistically significant （P〈0.05） .The time of disappearance of pelvic mass in the experimental group was shorter than that in the control group （P〈0.05）; the levels of VEGF and CA125 in the experimental group were lower than those in the control group （ P〈0.05 ） .There was no difference in safety between the two groups. Conclusion Conventional therapy plus safflower yellow pigment can promote the absorption of pelvic mass and reduce the levels of plasma D-D and β-HCG in the conservative treatment of ectopic pregnancy.