噻托溴铵和沙美特罗替卡松粉吸入剂联合无创呼吸机治疗呼吸衰竭患者的临床研究

Tiotropium and salmeterol xinafoate and fluticasone propionate powder for inhalation combined with non-invasive ventilation in respiratory failure

目的 探究采用噻托溴铵和沙美特罗替卡松粉吸入剂联合无创呼吸机治疗呼吸衰竭患者的临床疗效,为临床治疗提供参考。方法 选取72例呼吸衰竭患者,通过随机分组法随机分为治疗组与对照组,每组患者各36例。对照组患者采用常规无创呼吸机治疗,治疗组在常规无创呼吸机治疗的前提下给予噻托溴铵和沙美特罗替卡松粉吸入剂治疗。然后记录比较2组患者的运动耐量、PaCO_2、心率、pH值、呼吸频率、PaO_2。结果 经过治疗,2组患者的病情都有不同程度的好转,最终结果显示治疗组患者的平均住院时间明显减少,呼吸频率减慢为（28±5）次/min、心率减慢为（98±16）次/min,PaO_2增多为（72±3）mm Hg,PaCO_2减少为（57±17）mm Hg,pH值增高为（7.42±0.03）,与对照组比较,差异均具有统计学意义（P〈0.05）。结论 噻托溴铵和沙美特罗替卡松粉吸入剂联合无创呼吸机治疗呼吸衰竭,能够明显使患者病情获得好转,使患者的呼吸功能获得明显改善,使患者各项指标趋于正常。有效降低PaCO_2,升高PaO_2,加快其治愈速度。

Objective To explore the clinical efficacy of tiotropium and salmeterol xinafoate and fluticasone propionate powder for inhalation combined with noninvasive ventilator in the treatment of respiratory failure, and to provide reference for clinical treatment.Methods 72 patients with respiratory failure were randomly divided into treatment group （n=36） and control group （n=36）.The patients were randomly divided into treatment group and control group.Patients in the control group were treated with conventional noninvasive ventilators and treatment group were treated with tiotropium and salmeterol xinafoate and fluticasone propionate powder for inhalation on the basis of control group.Then compare the exercise tolerance, arterial carbon dioxide partial pressure, heart rate, pH, respiratory rate, blood oxygen pressure between two groups.Results After the treatment, condition of the patients in the two groups have different degrees of improvement.The final results showed that the average hospital stay was significantly reduced, respiratory frequency was（28 ±5） times/min in treatment group, heart rate was（98 ±16） times per minute, PaO2 also increased to（72 ±3） mmHg, PaCO2 was（57 ±17） mmHg, pH value increased to （7.42 ±0.03）, compared with the control group, with statistically significant difference （P〈0.05）.Conclusion In patients with clinical implementation of tiotropium and seretide combined with non-invasive ventilator treatment of respiratory failure, can significantly improve the patient＇s condition, so that patients with respiratory function was significantly improved, so that the indicators of patients tend to normal.Its can effectively reduce PaCO2 , increased PaO2 and speed up its cure rate.