普米克令舒雾化吸入对支原体肺炎患儿血清sICAM-1、SP-A、IGF-1水平的影响

Effects of pulmicort inhalation on serum sICAM-1, SP-A and IGF-1 levels in children with mycoplasma pneumonia

目的 观察分析普米克令舒雾化吸入对儿童支原体肺炎血清可溶性细胞间黏附分子-1（s ICAM-1）、肺表面活性物质相关蛋白A（SP-A）、胰岛素样生长因子-1（IGF-1）水平的影响情况。方法 选取2015年1月～2016年9月期间浙江省乐清市第二人民医院及温州医科大学附属二院收治的108例支原体肺炎患儿为研究对象,将其随机分为对照组和观察组,每组各54例,对照组进行常规治疗,观察组则在对照组常规治疗的基础上加用普米克令舒雾化吸入,将2组中不同严重程度患儿的临床总有效率、体征消失时间及治疗前后的血清s ICAM-1、SP-A、IGF-1水平进行分别比较。结果 观察组中轻度、中度及重度肺炎患儿的临床总有效率分别为100.00%、100.00%及93.33%,均高于对照组的84.21%、80.00%及73.33%,咳嗽、发热及肺部啰音消失时间分别为（4.54±0.66）d、（1.84±0.18）d及（3.76±0.52）d,均短于对照组的（7.10±0.82）d、（3.25±0.30）d及（5.88±0.75）d,治疗后1、3及5 d的血清sICAM-1及SP-A水平均低于对照组,血清IGF-1水平则高于对照组,差异有统计学意义（P〈0.05）。结论 普米克令舒雾化吸入在儿童支原体肺炎中的临床疗效较好,且对血清sICAM-1、SP-A、IGF-1水平有更为积极的调节作用。

Objective To observe the effect of atomized inhalation on the levels of serum sICAM-1, SP-A and IGF-1 in children with mycoplasma pneumonia.Methods 108 children with mycoplasma pneumonia in our hospital from January 2015 to September 2016 were selected as the study object, and they were randomly divided into control group and observation group with 54 cases in each group, the control group were treated with conventional treatment, the observation group were treated with pulmicort respules by aerosol inhalation on the basic treatment of control group , then the clinical effective rates and signs disappearing time of different severity degree, serum sICAM-1, SP-A and IGF-1 levels before and after the treatment of two groups were compared.Results The clinical effective rates of observation group with mild, moderate and severe disease were respectively 100.00%, 100.00% and 93.33%, and they were all higher than 84.21%, 80.00% and 73.33% of control group, and the cough, fever and pulmonary rales disappearing time were respectively （4.54 ±0.66）d, （1.84 ±0.18）d and （3.76 ±0.52）d, and they were all shorter than （7.10 ±0.82）d, （3.25 ± 0.30）d and （5.88 ±0.75）d of control group, the serum sICAM-1and SP-A at first, third and fifth day after the treatment were lower than those of control group, serum IGF-1 level were higher than those of control group, the difference was statistically significant （P〈0.05）, the differences were all significant.Conclusion The clinical effect of pulmicort respules by aerosol inhalation is better, and it has active adjustion role for the serum sICAM-1, SP-A and IGF-1.