精神分裂症患者服用抗精神病药物前后血清LDL-C、TG、TC水平变化及其临床意义

Changes and clinical significance of serum LDL-C,TG and TC levels before and after taking antipsychotic drugs in patients with schizophrenia

目的分析与探讨精神分裂症患者服药前后血脂水平的变化。方法回顾性分析63例于2014年8月至2016年8月在北京回龙观医院接受药物治疗的精神分裂症患者的临床资料。结果观察组患者服药8周后的低密度脂蛋白胆固醇(LDLC)、三酰甘油(TG)、总胆固醇(TC)水平与服药前相比均明显升高,差异有统计学意义(P<0.05);对照组患者服药8周后的各项指标水平与服药前相比,差异无统计学意义(P>0.05)。服药后1个月,观察组与对照组服药后进行阳性与阴性症状量表(PANSS)和日常生活活动能力(ADL)评分比较,观察组的不同症状评分以及一般精神病理和总分均显著低于对照组(P<0.05),进行生活质量SF-36健康问卷评分和比较,观察组各项得分均显著高于对照组(P<0.05)。结论研究表明,对精神分裂症患者实施利培酮口腔崩解片联合奥沙西泮治疗可以获得理想的临床效果,提高患者的日常生活能力和生活质量,有效改善患者LDL-C、TG、TC水平,减少各种不良反应的出现,是一种安全高效的治疗方案,值得推广。

Objective To analyze and investigate the changes of serum related lipid levels before and after taking antipsychotic drugs in the patients with schizophrenia.Methods The clinical data of 63 patients with schizophrenia treated in our hospital from August 2014 to August 2016 were retrospectively analyzed.Results The LDL-C,TG and TC levels at 8weeks after taking medication in the observation group were significantly increased,the difference was statistically significant compared with before treatment（P〈0.05）;while the levels of various indexes in the control group were all improved,but there was no significant difference compared with before treatment（P〉0.05）;the PANSS and ADL scores after medication had statistically significant difference between the two groups;the concerned different symptoms scores,general psychopathology and total scores of the observation group were significantly lower than those of the control group（P〈0.05）,the life quality SF-36 health questionnaire score and comparison after1 months of medication showed that the scores of various indexes in the observation group were significantly higher than those in the control group,the differences between groups were significantly significant（P〈0.05）.Conclusion The study shows that taking Risperidone Orally Disintegrating Tablets combined with oxazepam can obtain ideal clinical effect in treating schizophrenia.The combined treatment regimen can better improve the clinical symptoms of the patients,increases the ability of daily living and quality of life,effectively improves the LDL-C,TG and TC levels,effectively reduces various adverse reactions,and is a safe and effective treatment regimen and worthy of promotion.