不同分级急性胆道系统感染患者血清高迁移率族蛋白B1的对比研究

Comparative study on serum HMGB1 level in patients with different grades of acute biliary tract infection

目的对比分析不同严重程度的急性胆道系统感染(ABTI)患者血清高迁移率族蛋白B1(HMGB1)水平差异和特点,为临床诊断和治疗提供参考。方法将收治的100例ABTI患者根据病情严重程度分为轻度组(48例)、中度组(29例)和重度组(23例),对3组的HMGB1水平进行比较,分析3组中不同疾病类型、性别、年龄的患者HMGB1水平的差异。结果 (1)3组的HMGB1水平比较显示轻度组<中度组<重度组,差异有统计学意义(P<0.05);(2)轻度组和中度组中男性、女性患者间HMGB1水平比较差异无统计学意义(P>0.05),而重度组中男性的HMGB1水平明显高于女性患者(P<0.05);(3)轻度组中不同年龄段患者的HMGB1水平比较差异无统计意义(P>0.05),而中度组、重度组中年龄>60岁患者的HMGB1水平明显高于年龄≤60岁患者(P<0.05);(4)在上述3组中,急性胆囊炎患者的HMGB1水平均显著高于急性胆管炎患者(P<0.05)。结论ABTI患者病情越严重,其血清中的HMGB1的水平也越高。而对于不同严重程度的ABTI患者而言,其血清的HMGB1水平的高低在不同年龄、性别、疾病类型人群中的分布有所不同。这提示HMGB1水平可作为预测和反映ABTI严重程度的指标,值得在临床加以重视。

Objective To comparatively analyze the difference and characteristics of high mobility group box-1protein（HMGB1）level with the levels in the patients with different severities of acute biliary tract infection（ABTI）to provide reference for its clinical diagnosis and treatment.Methods One hundred cases of ABTI in our hospital were divided into the mild group（48cases）,moderate group（29cases）and severe group（23cases）according to the severity of the disease.The HMGB1 detection results were compared among 3groups and the differences in different disease types,sex and age were analyzed.Results（1）The HMGB1 level had statistically significant difference among 3groups（P〈0.05）,moreover the mild group moderate group severe group;（2）in the detection results,the HMGB1 level in the mild group and moderate group had no statistical difference between males and females（P〉0.05）,but in the severe group,the HMGB1 level in males was significantly higher than that in females（P〈0.05）;（3）the HMGB1 level in the mild group had no statistical difference among difference age groups（P〉0.05）,while in the moderate group and severe group,the HMGB1 level in the patients aged 〉60years old was significantly higher than that in the patients aged ≤60years old（P〈0.05）;（4）in the above 3groups,the HMGB1 level in the patients with acute cholecystitis was significantly higher than that in the patients with acute cholangitis（P〈0.05）.Conclusion The study results analysis indicates that the severe the ABTI disease condition,the serum HMGB1 level is also accordingly and relatively increased,in the patients with different severity degrees of ABTI,the serum HMGB1 level has significant differences in age,sex and disease type,which prompts that the HMGB1 level can be used as the laboratory index for predicting and reflecting the ABTI severity and can be paid attention to.