宜春市脑卒中高危人群生化联合指标的水平及相关性研究

Study on level and correlation of biochemical joint indicators among stroke high risk populations in Yichun City

目的了解宜春市脑卒中高危人群中生化联合指标的水平及相关性;以及宜春市社区与农村脑卒中高危人群联合生化指标的水平差异。方法在2015、2016年宜春市脑卒中筛查中的高危人群354例,其中社区高危人群115例、乡村239例;男226例、女128例,年龄40~86岁。非脑卒中高危人群共31例,男15例、女16例,年龄28~85岁。分别进行血糖(GLU)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)7项生化联合指标的检测、统计和分析。结果在脑卒中高危人群和对照组的比较中,CH、TG、LDL、Hcy的差异有统计学意义(P<0.05);HDL、GLU、HbA1c的差异无统计学意义(P>0.05)。在社区和农村的脑卒中高危组的比较中,CH、TG、LDL、GLU的差异有统计学意义(P<0.05);HDL、Hcy、HbA1c的差异无统计学意义(P>0.05)。结论 CH、TG、LDL、Hcy升高是脑卒中的高危因素,而CH、TG、LDL、Hcy是可干预危险因素,在早期诊治、预后中起着重要作用。预防脑卒中的关键是健康的饮食、良好的生活习惯,适量的运动、定期对CH、TG、LDL、Hcy、GLU监测、预警、防治,可使脑卒中不发生或少发生,从而降低发病率。大大减少发病率、复发率,减少家庭和社会的人力、物力、财力等负担。

Objective To understand the level and correlation of biochemical joint indicators in stroke high risk population in Yichun City,and the differences in biochemical joint indicators between community and rural stroke high risk populations.MethodsThree hundreds and fifty-four high risk people during stroke screening in 2015 and 2016included 115 community high risk cases,239 rural cases,226 males and 128 females,aged 40 to 86years old.Thirty-one cases of non-stroke high risk included 15 cases of male and 16 cases of female,aged 28 to 85years old.Seven biochemical joint indicators were detected and statistically analyzed,including glucose（GLU）,glycated hemoglobin（HbA1c）,total cholesterol（TC）,triacylglycerin（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）and homocysteine（Hcy）.Results In the comparison between stroke high risk population and non-high risk populations,CH,TG,LDL-C and Hcy had statistically significant difference（P〈0.05）.HDL-C,GLU,HbA1 chad no statistically significant difference（P〉0.05）.In the comparison between community and rural stroke high risk populations,CH,TG,LDL-C and GLU had statistically significant difference（P〈0.05）;HDL-C,Hcy and HbA1 chad no statistically significant difference（P〉0.05）.Conclusion The increase of CH,TG,LDL-C and Hcy is the risk factors of stroke,while CH,TG,LDL-C and Hcy are the interventional risk factors and play an important role in its early diagnosis,treatment and prognosis.The key to prevent stroke is the healthy diet,good living habits,moderate exercises,and regular monitoring of CH,TG,LDL-C,Hcy and GLU,forewarning,prevention and treatment,which can avoid the occurrence or less occurrence of stroke,thus reduces the its incidence rate,greatly decrease the morbidity,recurrence rate,and reduces the familial and social burden of manpower,material resources and financial resources.