新辅助化疗在软组织肉瘤治疗中的应用分析

The Analysis of Application of Neoadjuvant Chemotherapy in the Treatment of Soft Tissue Sarcoma

目的研究并探讨新辅助化疗在软组织肉瘤治疗中的应用效果。方法选取2013年1月—2016年6月期间甘肃中医药大学临床医学院收治的软组织肉瘤共80例作为研究对象,采取单盲随机分组法随机分为对照组和观察组各40例,对照组实施手术治疗,观察组在手术前实施新辅助化疗,比较两组患者的保肢率、治疗效果、术后半年复发情况。结果观察组患者的保肢手术率为77.50%,对照组患者为55.00%,差异具有统计学意义(P<0.05);观察组患者的治疗总有效率明显高于对照组(P<0.05);术后半年随访发现,观察组的复发率明显低于对照组(P<0.05);观察组患者在新辅助化疗期间未出现严重的不良反应。结论在软组织肉瘤患者行手术治疗前实施新辅助化疗,可提高患者的保肢率,提高治疗效果,减少复发,有利于改善预后。

Objective To study and explore the application of neoadjuvant chemotherapy in the treatment of soft tissue sarcoma.Methods From January 2013 to June 2016 our hospital during the period of soft tissue sarcoma 80 cases as the research object,take the single blind random grouping randomly divided into two groups（40 cases,control group treatment with surgery,observation group of preoperative neoadjuvant chemotherapy,compared two groups of patients with limb salvage rate,treatment effect and postoperative recurrence of half a year.Results The observation group of patients with limb-salvage surgery at a rate of 77.50%,control group patients was 55.00%,the difference is statistically significant（P〈0.05）; The treatment of patients with total effective observation group was obviously higher than that of control group（P〈0.05）; Postoperative follow-up found six months,the recurrence rate of observation group was obviously lower than the control group（P〈0.05）; Observation group of patients during neoadjuvant chemotherapy does not appear serious adverse reactions.Conclusion In patients with soft tissue sarcomas line implementation of neoadjuvant chemotherapy before surgery,patients can improve the limb salvage rate,improve the treatment effect,reduce recurrence and to improve prognosis.