热性药附子、肉桂、桂枝与干姜对寒性药大黄致泻作用的影响

Effect on purgative induced by rheum officinale of aconite,cinnamon,cassia twig

目的:通过考察4味热性药分别以不同比例配伍寒性药大黄之后对其致泻的影响来探究寒热对药配伍的制约偏性作用。方法:随机将小鼠分为空白组与药物组,空白组仅给予蒸馏水,药物组分别给予各相应药物提取液,观察各组小鼠的首次排便时间、4 h的排便总量及炭末推进率。结果:不管是以水还是乙醇作为提取溶媒,随着4味热性药在药液中所占比例的升高均对大黄致泻性产生抑制,尤以水为提取溶媒时,抑制性增强的趋势更明显,且呈现良好线性关系。结论:大黄配伍4味不同的热性药之后,均明显制约了大黄的致泻偏性,且热性药所占比例与其抑制大黄致泻偏性的作用线性相关性良好。从药效学的角度为中药传统寒热配伍制约偏性的理论提供了实验依据。

Objective：To study the restriction bias effect of Chinese medicine by using four kinds of hot medicine respectively and cold medicine（rheum officinale）of incompatibility with different proportions. Method：Mice were randomly divided into control group and medicine groups,the control group was given distilled water,the medicine groups were given the corresponding medicine extraction. The first defecation time,the total amount of 4 h and the advancing rate of charcoal were observed in each group. Result：Whether in water or ethanol as extraction solvent,with the increase the proportion of four kinds of hot medicine,the purgative effect of rheum officinale was inhibited,especially in the water as the extraction solvent and the inhibition of the trend was more obvious which showed a good linear relationship. Conclusion：The purgative effect of rheum officinale is inhibited after rheum officinale combined with four different kinds of hot medicine,and the linear correlation between proportion of hot medicine and the inhibition of induced diarrhea is good. The restriction bias experiment theories basis on compatibility in cold and hot medicine of Chinese medicine was provided from the perspective of pharmacodynamics.