SOCS1调控小胶质细胞活化水平的最新研究进展

Recent advances in SOCS1 modulating microglial activation research

小胶质细胞过度活化可加剧中枢神经系统(CNS)炎症反应,引起中枢神经功能损害,小胶质细胞活化参与了脑中风、神经退行性疾病和脑外伤的发生与发展。因此,抑制小胶质细胞过度活化是防治多种CNS疾病的重要手段。细胞因子抑制信号蛋白1(SOCS1)是表达于小胶质细胞上的一种蛋白,大量研究表明,SOCS1蛋白表达变化可调控小胶质细胞活化水平,抑制小胶质细胞过度活化、降低CNS炎症因子浓度和炎症反应程度。白藜芦醇和姜黄素等生物活性药物还可通过增加小胶质细胞SOCS1表达,显著降低β淀粉样蛋白(Aβ)对小胶质细胞的活化水平并降低促炎症因子释放量,因此,SOCS1可能作为新的干预靶点,用于防治阿尔兹海默症等慢性CNS退行性疾病。

Over-activation of microglia can enhance the inflammation of central nervous system( CNS),damage the neurological functions and is involved in the development and pathogenesis of stroke,neurodegenerative diseases and traumatic brain injury. Therefore,inhibiting microglial over-activation is an effective therapy for the diseases. Suppressor of Cytokine Signaling 1( SOCS1) is a protein expressed in microglial cells,and some latest investigations showed that up-regulation of SOCS1 can modulate microglial activation,reduce inflammatory cytokines' releases and descend neuroinflammation. Resveratrol and curcumin can reduce microglial activation by increasing SOCS1 protein expression. In addition,resveratrol and curcumin can reduce β amyloid-induced microglial activation and decrease neuroinflammation. These investigations showed that SOCS1 may be a novel therapeutic target for Alzheimer's disease and other inflammatory neural disorders.