尤瑞克林用于急性大脑中动脉脑梗死的疗效及对神经功能的影响

Efficacy of Urinarykallid in Treatment of Acute Middle Cerebral Artery Infarction and Effects on Nerve Function

目的:探讨尤瑞克林对急性大脑中动脉脑梗死患者的临床效果及对神经功能的影响。方法:选取2014年5月—2016年5月牡丹江医学院红旗医院收治的急性大脑中动脉脑梗死患者80例作为研究对象,以随机数字表法分为观察组和对照组,每组各40例。对照组患者给予常规治疗,观察组患者在对照组基础上加用尤瑞克林治疗。采用美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、日常生活能力量表(activity of daily living scale,ADL)、改良残疾程度量表(modified rankin scale,mRS)分别评估患者的神经功能缺损程度、日常生活活动能力、残疾程度改良情况,并观察2组患者疗效及不良反应发生情况。结果:观察组患者的NIHSS评分、mRS评分均显著低于对照组,ADL评分显著高于对照组,差异均有统计学意义(P<0.05)。观察组患者的总有效率为77.5%(31/40),显著高于对照组50.0%(20/40),差异有统计学意义(P<0.05)。2组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:尤瑞克林治疗急性大脑中动脉脑梗死,可有效改善患者的神经功能,提高患者的治疗总有效性。

OBJECTIVE：To investigate the efficacy of urinarykallid in treatment of acute middle cerebral artery infarction and effects on nerve function. METHODS： 80 patients with acute middle cerebral artery infarction admitted into Hongqi Hospital of Mudanjiang Medical College from May 2015 to May 2016 were selected to be divided into observation group and control group via the random number table, with 40 cases in each. The control group were given conventional treatment, while the observation group additionally received urinarykallid based on the control group. The neurological function deficiency scale, activity of daily life, improvement of handicapped degree were evaluated by national institute of health stroke scale （NIHSS）, activity of daily living scale （ADL） and modified rankin scale （mRS）. The efficacy and incidence of adverse drug reactions of two groups were observed. RESULTS： The NIHSS score, mRS score of observation group were significantly lower than those of control group, and ADL score was higher than that of control group, with statistical significance （ P 〈 0. 05 ）. The total effective rate of observation group was 77.5 % （ 31/40）, significantly higher than that of control group [ 50. 0% （20/40） ], with statistical significance （ P 〈 0. 05）. There was no statistical significance between two groups in the incidence of adverse drug reactions（P 〉 0. 05 ）. CONCLUSIONS ： Urinarykallid in treatment of acute middle cerebral artery infarction can effectively improve the nerve function of patients and improve the total treatment effectiveness of patients.