血清前白蛋白与急性冠脉综合征相关性的研究

The research of correlation between prealbumin and acute coronary syndrome

目的 探讨急性冠脉综合征（ACS）患者血清前白蛋白（PA）水平变化的临床意义.方法 选择2013年8月至2014年2月在江苏省南通市第一人民医院心内科住院的ACS患者110例,其中男性69例、女性41例;正常对照组96例.检测血清PA水平,同时记录ACS组患者30 d内主要不良心脏事件（MACE）的发生情况,包括恶性心律失常、新发心力衰竭、心源性死亡、再发心肌梗死.再根据PA中位数将ACS组分为高PA组和低PA组,比较两组间30 d内MACE的发生率.结果 ACS组的血清PA水平较正常对照组低[（153.48±3.95）mg/L比（238.38±3.45）mg/L,P＜0.05].PA与高敏C反应蛋白（hs-CRP）呈负相关（r=-0.318,P＜ 0.05）.低PA组患者30 d内MACE的总发生率较高PA组明显增加（81.81％比47.27％,P＜0.05）.结论 ACS患者的血清PA水平明显降低,低PA值提示ACS患者短期预后不良.

Objective To study the significance of prealbumin＇s change in patients with acute coronary syndrome. Methods We selected 110 subjects because of ACS admitted into Cardiology Department of Nantong First People＇s Hospital from August 2013 to February 2014, which 69 males and 41 females. Another 90 healthy people were included as control group. Level of PA was measured in both of them. Moreover, main adverse cardiac events（MACE ） were recorded with 30-days follow-up. In addition, trial group were divided by median of PA into two groups： high PA group and low PA group, then compare the incidence rate of MACE. Results Level of PAin serum was significantly lower in patients with ACS than that in control group. Compared with high PA group [ （238.38±3.45）mg/L vs （153.48±3.95）mg/L, P〈0.05 ], PA and was negatively correlated with high-sensitivity C-reactive protein （hs-CRP）（r=-0.318, P〈0.05 ）, the incidence rate of MACE in low PA group was observably higher （81.81% vs 47.27%, P〈0.05）. Conclusion Level of PA in serum is markedly decease in patients with ACS, which can be used for short-term prognosis for ACS.